The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy

Kyoung Heo, Yumie Rhee, Hyang Woon Lee, Sang Ahm Lee, Dong Jin Shin, Won Joo Kim, Hong Ki Song, Kijun Song, Byung In Lee

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six women on long-term (at least 1 year) topiramate monotherapy were compared with 36 women taking carbamazepine, 32 women taking valproate, and 36 age- and sex-matched controls. Subjects completed bone mineral density (BMD) studies. Serum was analyzed for indices of bone metabolism. Key Findings: BMD Z-scores, and serum 25-hydroxyvitamin D and 1alpha,25-dihydroxyvitamin D 3 concentrations did not differ among the groups. Serum calcium concentrations were significantly lower in patients receiving topiramate than in those receiving valproate, and in patients receiving carbamazepine than in those receiving valproate and controls. Patients taking topiramate had lower levels of parathyroid hormone compared with controls and those taking carbamazepine or valproate. Patients receiving topiramate had higher levels of bone-specific alkaline phosphatase and osteocalcin when compared with controls and higher levels of C-terminal telopeptide of type 1 collagen when compared with those taking carbamazepine or valproate. Patients receiving carbamazepine had higher levels of bone-specific alkaline phosphatase compared with controls and those receiving valproate. Serum bicarbonate concentrations were significantly lower in patients receiving topiramate than in the other groups. Significance: Our results demonstrate that use of topiramate is associated with lower parathyroid hormone and bicarbonate concentrations along with mild hypocalcemia and increased bone turnover, which suggests that topiramate may have long-term effects on bone.

Original languageEnglish
Pages (from-to)1884-1889
Number of pages6
JournalEpilepsia
Volume52
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

Fingerprint

Bone Density
Minerals
Epilepsy
Valproic Acid
Carbamazepine
Bone and Bones
Bicarbonates
Parathyroid Hormone
Serum
Alkaline Phosphatase
Dihydroxycholecalciferols
Hypocalcemia
topiramate
Bone Remodeling
Osteocalcin
Collagen Type I
Calcium

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Heo, Kyoung ; Rhee, Yumie ; Lee, Hyang Woon ; Lee, Sang Ahm ; Shin, Dong Jin ; Kim, Won Joo ; Song, Hong Ki ; Song, Kijun ; Lee, Byung In. / The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. In: Epilepsia. 2011 ; Vol. 52, No. 10. pp. 1884-1889.
@article{31645974586a4a6497bcc0c709ffedfc,
title = "The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy",
abstract = "Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six women on long-term (at least 1 year) topiramate monotherapy were compared with 36 women taking carbamazepine, 32 women taking valproate, and 36 age- and sex-matched controls. Subjects completed bone mineral density (BMD) studies. Serum was analyzed for indices of bone metabolism. Key Findings: BMD Z-scores, and serum 25-hydroxyvitamin D and 1alpha,25-dihydroxyvitamin D 3 concentrations did not differ among the groups. Serum calcium concentrations were significantly lower in patients receiving topiramate than in those receiving valproate, and in patients receiving carbamazepine than in those receiving valproate and controls. Patients taking topiramate had lower levels of parathyroid hormone compared with controls and those taking carbamazepine or valproate. Patients receiving topiramate had higher levels of bone-specific alkaline phosphatase and osteocalcin when compared with controls and higher levels of C-terminal telopeptide of type 1 collagen when compared with those taking carbamazepine or valproate. Patients receiving carbamazepine had higher levels of bone-specific alkaline phosphatase compared with controls and those receiving valproate. Serum bicarbonate concentrations were significantly lower in patients receiving topiramate than in the other groups. Significance: Our results demonstrate that use of topiramate is associated with lower parathyroid hormone and bicarbonate concentrations along with mild hypocalcemia and increased bone turnover, which suggests that topiramate may have long-term effects on bone.",
author = "Kyoung Heo and Yumie Rhee and Lee, {Hyang Woon} and Lee, {Sang Ahm} and Shin, {Dong Jin} and Kim, {Won Joo} and Song, {Hong Ki} and Kijun Song and Lee, {Byung In}",
year = "2011",
month = "10",
day = "1",
doi = "10.1111/j.1528-1167.2011.03131.x",
language = "English",
volume = "52",
pages = "1884--1889",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "10",

}

The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. / Heo, Kyoung; Rhee, Yumie; Lee, Hyang Woon; Lee, Sang Ahm; Shin, Dong Jin; Kim, Won Joo; Song, Hong Ki; Song, Kijun; Lee, Byung In.

In: Epilepsia, Vol. 52, No. 10, 01.10.2011, p. 1884-1889.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy

AU - Heo, Kyoung

AU - Rhee, Yumie

AU - Lee, Hyang Woon

AU - Lee, Sang Ahm

AU - Shin, Dong Jin

AU - Kim, Won Joo

AU - Song, Hong Ki

AU - Song, Kijun

AU - Lee, Byung In

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six women on long-term (at least 1 year) topiramate monotherapy were compared with 36 women taking carbamazepine, 32 women taking valproate, and 36 age- and sex-matched controls. Subjects completed bone mineral density (BMD) studies. Serum was analyzed for indices of bone metabolism. Key Findings: BMD Z-scores, and serum 25-hydroxyvitamin D and 1alpha,25-dihydroxyvitamin D 3 concentrations did not differ among the groups. Serum calcium concentrations were significantly lower in patients receiving topiramate than in those receiving valproate, and in patients receiving carbamazepine than in those receiving valproate and controls. Patients taking topiramate had lower levels of parathyroid hormone compared with controls and those taking carbamazepine or valproate. Patients receiving topiramate had higher levels of bone-specific alkaline phosphatase and osteocalcin when compared with controls and higher levels of C-terminal telopeptide of type 1 collagen when compared with those taking carbamazepine or valproate. Patients receiving carbamazepine had higher levels of bone-specific alkaline phosphatase compared with controls and those receiving valproate. Serum bicarbonate concentrations were significantly lower in patients receiving topiramate than in the other groups. Significance: Our results demonstrate that use of topiramate is associated with lower parathyroid hormone and bicarbonate concentrations along with mild hypocalcemia and increased bone turnover, which suggests that topiramate may have long-term effects on bone.

AB - Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six women on long-term (at least 1 year) topiramate monotherapy were compared with 36 women taking carbamazepine, 32 women taking valproate, and 36 age- and sex-matched controls. Subjects completed bone mineral density (BMD) studies. Serum was analyzed for indices of bone metabolism. Key Findings: BMD Z-scores, and serum 25-hydroxyvitamin D and 1alpha,25-dihydroxyvitamin D 3 concentrations did not differ among the groups. Serum calcium concentrations were significantly lower in patients receiving topiramate than in those receiving valproate, and in patients receiving carbamazepine than in those receiving valproate and controls. Patients taking topiramate had lower levels of parathyroid hormone compared with controls and those taking carbamazepine or valproate. Patients receiving topiramate had higher levels of bone-specific alkaline phosphatase and osteocalcin when compared with controls and higher levels of C-terminal telopeptide of type 1 collagen when compared with those taking carbamazepine or valproate. Patients receiving carbamazepine had higher levels of bone-specific alkaline phosphatase compared with controls and those receiving valproate. Serum bicarbonate concentrations were significantly lower in patients receiving topiramate than in the other groups. Significance: Our results demonstrate that use of topiramate is associated with lower parathyroid hormone and bicarbonate concentrations along with mild hypocalcemia and increased bone turnover, which suggests that topiramate may have long-term effects on bone.

UR - http://www.scopus.com/inward/record.url?scp=80053566974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053566974&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2011.03131.x

DO - 10.1111/j.1528-1167.2011.03131.x

M3 - Article

VL - 52

SP - 1884

EP - 1889

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 10

ER -