The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy

A Pilot Randomized Controlled Trial

Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Youngdeuk Choi, Eunju Choi, Youngkyu Song, Hosook Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. Objective: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. Methods: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25). Primary outcomes were bone mineral density and bone turnover markers. Secondary outcomes were physical performance (level of physical activity, muscle strength, and balance) and health-related quality of life. Results: The patient retention rate for 6 months was 80.4%. The mean adherence rate was 84.7% for weight-bearing exercise and 64.8% for resistance exercise. No adverse events during the study period were reported. Although primary outcomes did not differ significantly between the 2 groups, the home-based exercise intervention for preventing osteoporosis group demonstrated significantly greater increased muscle strength than the stretching exercise group. Conclusions: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. Implications for Practice: Given the importance of preventing cancer treatment-induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.

Original languageEnglish
Pages (from-to)379-388
Number of pages10
JournalCancer Nursing
Volume41
Issue number5
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Androgens
Survivors
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Bone and Bones
Muscle Strength
Therapeutics
Osteoporosis
Muscle Stretching Exercises
Group Homes
Bone Remodeling
Weight-Bearing
Bone Density
Neoplasms
Placebos
Quality of Life

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oncology(nursing)

Cite this

Kim, Soo Hyun ; Seong, Do Hwan ; Yoon, Sang Min ; Choi, Youngdeuk ; Choi, Eunju ; Song, Youngkyu ; Song, Hosook. / The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy : A Pilot Randomized Controlled Trial. In: Cancer Nursing. 2018 ; Vol. 41, No. 5. pp. 379-388.
@article{8c0cb5478a854ccfbc7c3ace81ebe468,
title = "The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy: A Pilot Randomized Controlled Trial",
abstract = "Background: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. Objective: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. Methods: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25). Primary outcomes were bone mineral density and bone turnover markers. Secondary outcomes were physical performance (level of physical activity, muscle strength, and balance) and health-related quality of life. Results: The patient retention rate for 6 months was 80.4{\%}. The mean adherence rate was 84.7{\%} for weight-bearing exercise and 64.8{\%} for resistance exercise. No adverse events during the study period were reported. Although primary outcomes did not differ significantly between the 2 groups, the home-based exercise intervention for preventing osteoporosis group demonstrated significantly greater increased muscle strength than the stretching exercise group. Conclusions: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. Implications for Practice: Given the importance of preventing cancer treatment-induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.",
author = "Kim, {Soo Hyun} and Seong, {Do Hwan} and Yoon, {Sang Min} and Youngdeuk Choi and Eunju Choi and Youngkyu Song and Hosook Song",
year = "2018",
month = "9",
day = "1",
doi = "10.1097/NCC.0000000000000530",
language = "English",
volume = "41",
pages = "379--388",
journal = "Cancer Nursing",
issn = "0162-220X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy : A Pilot Randomized Controlled Trial. / Kim, Soo Hyun; Seong, Do Hwan; Yoon, Sang Min; Choi, Youngdeuk; Choi, Eunju; Song, Youngkyu; Song, Hosook.

In: Cancer Nursing, Vol. 41, No. 5, 01.09.2018, p. 379-388.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy

T2 - A Pilot Randomized Controlled Trial

AU - Kim, Soo Hyun

AU - Seong, Do Hwan

AU - Yoon, Sang Min

AU - Choi, Youngdeuk

AU - Choi, Eunju

AU - Song, Youngkyu

AU - Song, Hosook

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. Objective: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. Methods: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25). Primary outcomes were bone mineral density and bone turnover markers. Secondary outcomes were physical performance (level of physical activity, muscle strength, and balance) and health-related quality of life. Results: The patient retention rate for 6 months was 80.4%. The mean adherence rate was 84.7% for weight-bearing exercise and 64.8% for resistance exercise. No adverse events during the study period were reported. Although primary outcomes did not differ significantly between the 2 groups, the home-based exercise intervention for preventing osteoporosis group demonstrated significantly greater increased muscle strength than the stretching exercise group. Conclusions: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. Implications for Practice: Given the importance of preventing cancer treatment-induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.

AB - Background: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. Objective: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. Methods: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25). Primary outcomes were bone mineral density and bone turnover markers. Secondary outcomes were physical performance (level of physical activity, muscle strength, and balance) and health-related quality of life. Results: The patient retention rate for 6 months was 80.4%. The mean adherence rate was 84.7% for weight-bearing exercise and 64.8% for resistance exercise. No adverse events during the study period were reported. Although primary outcomes did not differ significantly between the 2 groups, the home-based exercise intervention for preventing osteoporosis group demonstrated significantly greater increased muscle strength than the stretching exercise group. Conclusions: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. Implications for Practice: Given the importance of preventing cancer treatment-induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85025433355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025433355&partnerID=8YFLogxK

U2 - 10.1097/NCC.0000000000000530

DO - 10.1097/NCC.0000000000000530

M3 - Article

VL - 41

SP - 379

EP - 388

JO - Cancer Nursing

JF - Cancer Nursing

SN - 0162-220X

IS - 5

ER -