The effectiveness of postoperative chemotherapy on pT1bN0 and pT2N0 gastric cancer patients with risk factors: An international dual-center analysis

Kun Yang, Mo Xi Chen, Yoon Young Choi, Zong Guang Zhou, Woo Jin Hyung, Sung Hoon Noh, Jian Kun Hu

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study aimed to investigate the effectiveness of postoperative chemotherapy in pT1bN0 and pT2N0 gastric cancer patients with high risk factors. Materials and Methods: Clinicopathological data of gastric cancer patients, who had undergone gastrectomy in high volume centers in Korea and China and were finally diagnosed with pT1bN0 and pT2N0 between 2006 and 2010, were analyzed retrospectively. Survival analyses stratified by risk factors and multivariable analyses were performed. Results: A total of 1509 patients were enrolled, with 41 (2.7%) patients receiving adjuvant chemotherapy after gastrectomy and 1468 (97.3%) patients undergoing surgery alone. The adjuvant chemotherapy group showed higher percentages of tumor with maximal diameter >3 cm (51.2% vs. 25.8%), poor differentiation (68.3% vs. 49.8%), and less harvested lymph nodes (17.1% vs. 5.2%) compared to the surgery alone group. The overall survival rates were 95.1% in the adjuvant chemotherapy group and 93.3% in the surgery alone group, without significant difference. In multivariable analysis, age was found to be an independent prognostic factor. However, there were no difference in the overall survival between patients with risk factors and those without risk factors, even in terms of age. Meanwhile, patients with more than two risk factors who received chemotherapy showed better survival trend, especially for pT2N0 patients, compared to the surgery alone group, although no significant differences were observed. Conclusion: In pT1bN0 and pT2N0 patients, age was found to be an independent prognostic factor. However, adjuvant chemotherapy seemed to be unnecessary, while postoperative chemotherapy might offer survival benefits to pT2N0 patients with more than two risk factors.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalYonsei medical journal
Volume62
Issue number2
DOIs
Publication statusPublished - 2021 Feb

Bibliographical note

Funding Information:
This work was internally supported by the Volunteer Team of Gastric Cancer Surgery (VOLTGA), West China Hospital, Sichuan University, PR China. The authors would like to thank Galiullin Danil (Department of Gastrointestinal Surgery, West China Hospital, Sichuan University), a native English speaker, for editing the English language in this manuscript. Domestic support from 1) National Natural Science Foundation of China (No. 81772547); 2) Fundamental Research Funds for the Central Universities (No. 2017SCU04A18); 3) Young Scientific and Academic Leaders Training Program of Sichuan University (No. 0082604151001/035); 4) Foundation of Science & Technology Department of Sichuan Province (No. 2019YFS0256); 5) 1. 3. 5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZY2017304).

Publisher Copyright:
© Yonsei University College of Medicine 2021.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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