Abstract
Purpose: To investigate improvement in nocturia and nocturnal polyuria in nocturnal polyuria patients after silodosin administration by using a 3-day frequency volume chart. Methods: This was a prospective multicenter study. We enrolled nocturnal polyuria patients (nocturnal polyuria index [NPi] > 0.33), aged ≥60 years, diagnosed with the 3-day frequency volume charts of patients with benign prostatic hyperplasia taking a-blockers. Of the 54 patients, 30 (55.6%) completed the study according to the study protocol (per-protocol group), and 24 dropped out (dropout group). Results: Of the 24 patients in the dropout group, 5 withdrew consent due to side effects or lack of efficacy, 7 were lost to follow- up at 4 weeks, 8 were lost to follow-up at 12 weeks, and 4 dropped out due to failure to complete 3-day frequency volume charts at 12 weeks. In the per-protocol group, there was significant improvement in the International Prostate Symptom Score (IPSS), especially question numbers 1, 3, 4, 5, 6, 7, and the quality of life question (P = 0.001, P = 0.007, P < 0.001, P = 0.003, P = 0.049, P < 0.001, and P < 0.001, respectively). The Leeds sleep evaluation questionnaire (LSEQ) score for the sleep question improved from 64.36 to 70.43 (P = 0.039). The NPi reduced from 0.4005 to 0.3573 (P = 0.027); however, in many cases, there was no improvement in nocturnal polyuria itself. In intention-to-treat analysis, there were significant improvements in IPSS and LSEQ in 45 patients. Conclusions: In elderly nocturnal polyuria patients, silodosin monotherapy exhibits good efficacy in improving nocturia and nocturnal polyuria; however, the mean NPi was still > 0.33. Considering the high dropout rate of our study due to no implementation of 3-day frequency volume charts, prospective and large-scale studies are needed to confirm our results.
| Original language | English |
|---|---|
| Pages (from-to) | 190-196 |
| Number of pages | 7 |
| Journal | International Neurourology Journal |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Urology
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The effectiveness of silodosin for nocturnal polyuria in elderly men with benign prostatic hyperplasia : A multicenter study. / Kim, Young Won; Park, Jinsung; Chung, Hong; Kim, Hong Wook; Kim, Hyung Joon; Jung, Jaehung; Kim, Won Tae.
In: International Neurourology Journal, Vol. 19, No. 3, 01.01.2015, p. 190-196.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effectiveness of silodosin for nocturnal polyuria in elderly men with benign prostatic hyperplasia
T2 - A multicenter study
AU - Kim, Young Won
AU - Park, Jinsung
AU - Chung, Hong
AU - Kim, Hong Wook
AU - Kim, Hyung Joon
AU - Jung, Jaehung
AU - Kim, Won Tae
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose: To investigate improvement in nocturia and nocturnal polyuria in nocturnal polyuria patients after silodosin administration by using a 3-day frequency volume chart. Methods: This was a prospective multicenter study. We enrolled nocturnal polyuria patients (nocturnal polyuria index [NPi] > 0.33), aged ≥60 years, diagnosed with the 3-day frequency volume charts of patients with benign prostatic hyperplasia taking a-blockers. Of the 54 patients, 30 (55.6%) completed the study according to the study protocol (per-protocol group), and 24 dropped out (dropout group). Results: Of the 24 patients in the dropout group, 5 withdrew consent due to side effects or lack of efficacy, 7 were lost to follow- up at 4 weeks, 8 were lost to follow-up at 12 weeks, and 4 dropped out due to failure to complete 3-day frequency volume charts at 12 weeks. In the per-protocol group, there was significant improvement in the International Prostate Symptom Score (IPSS), especially question numbers 1, 3, 4, 5, 6, 7, and the quality of life question (P = 0.001, P = 0.007, P < 0.001, P = 0.003, P = 0.049, P < 0.001, and P < 0.001, respectively). The Leeds sleep evaluation questionnaire (LSEQ) score for the sleep question improved from 64.36 to 70.43 (P = 0.039). The NPi reduced from 0.4005 to 0.3573 (P = 0.027); however, in many cases, there was no improvement in nocturnal polyuria itself. In intention-to-treat analysis, there were significant improvements in IPSS and LSEQ in 45 patients. Conclusions: In elderly nocturnal polyuria patients, silodosin monotherapy exhibits good efficacy in improving nocturia and nocturnal polyuria; however, the mean NPi was still > 0.33. Considering the high dropout rate of our study due to no implementation of 3-day frequency volume charts, prospective and large-scale studies are needed to confirm our results.
AB - Purpose: To investigate improvement in nocturia and nocturnal polyuria in nocturnal polyuria patients after silodosin administration by using a 3-day frequency volume chart. Methods: This was a prospective multicenter study. We enrolled nocturnal polyuria patients (nocturnal polyuria index [NPi] > 0.33), aged ≥60 years, diagnosed with the 3-day frequency volume charts of patients with benign prostatic hyperplasia taking a-blockers. Of the 54 patients, 30 (55.6%) completed the study according to the study protocol (per-protocol group), and 24 dropped out (dropout group). Results: Of the 24 patients in the dropout group, 5 withdrew consent due to side effects or lack of efficacy, 7 were lost to follow- up at 4 weeks, 8 were lost to follow-up at 12 weeks, and 4 dropped out due to failure to complete 3-day frequency volume charts at 12 weeks. In the per-protocol group, there was significant improvement in the International Prostate Symptom Score (IPSS), especially question numbers 1, 3, 4, 5, 6, 7, and the quality of life question (P = 0.001, P = 0.007, P < 0.001, P = 0.003, P = 0.049, P < 0.001, and P < 0.001, respectively). The Leeds sleep evaluation questionnaire (LSEQ) score for the sleep question improved from 64.36 to 70.43 (P = 0.039). The NPi reduced from 0.4005 to 0.3573 (P = 0.027); however, in many cases, there was no improvement in nocturnal polyuria itself. In intention-to-treat analysis, there were significant improvements in IPSS and LSEQ in 45 patients. Conclusions: In elderly nocturnal polyuria patients, silodosin monotherapy exhibits good efficacy in improving nocturia and nocturnal polyuria; however, the mean NPi was still > 0.33. Considering the high dropout rate of our study due to no implementation of 3-day frequency volume charts, prospective and large-scale studies are needed to confirm our results.
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UR - http://www.scopus.com/inward/citedby.url?scp=84945589211&partnerID=8YFLogxK
U2 - 10.5213/inj.2015.19.3.190
DO - 10.5213/inj.2015.19.3.190
M3 - Article
VL - 19
SP - 190
EP - 196
JO - International Neurourology Journal
JF - International Neurourology Journal
SN - 2093-4777
IS - 3
ER -