The effects of calcium phosphate-chitosan block bone graft on the periodontal regeneration in one wall intrabony defects in beagle dogs

Sung Koo Kim, Jung Seok Lee, Gyung Joon Chae, Ui Won Jung, Yong Keun Lee, Chong Kwan Kim, Seong Ho Choi

Research output: Contribution to journalArticle


This study evaluated periodontal repair and biomaterial reaction following implantation of a newly fabricated calcium phosphate chitosan block bone and chitosan membrane on the regeneration of 1- wall intrabony defects in the beagle dogs. The surgical control group received a flap operation only, while experimental group was treated with calcium phosphate chitosan block bone and/or chitosan membrane. All dogs were uneventful healing without any complication. The subjects were sacrificed 8 weeks after the experimental surgery, and a comparative histological and histometric examination was done. Chitosan membrane group significantly enhanced bone regeneration compared to control, CaP-chitosan block bone and combination group. Chitosan membrane remnants were observed in chitosan and combination group, while CaP-chitosan bone materials were resorbed completely. These results suggest that Chitosan membrnae significantly enhanced bone and cementum formation in advanced periodontal defects.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2007 Apr 16


All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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