The effects of chitosan-tetracycline membrane on periodontal regeneration of one-wall intrabony defects in beagle dogs

Kwang Hee Han, Gyung Joon Chae, Jung Yoo Choi, Ui Won Jung, Yong Keun Lee, Seong Ho Choi

Research output: Contribution to journalArticle


The aim of this study was to evaluate the regenerative effects of chitosan membranes containing tetracycline (TC) applied to surgically created one-wall intrabony defects in beagle dogs. The defects either received chitosan membrane (CH), chitosan membrane containing 0.5%, 1% TC (CH-TC0.5, CH-TC1.0) or flap operation only. The animals were sacrificed 8 weeks after the experimental surgery, and comparative histological and histometric examinations were done. The amount of junctional epithelium migration and connective tissue adhesion did not show any statistically significant differences among the groups. The amount of new cementum regeneration, and new bone regeneration were significantly greater in CH-TC1.0 group than the control (P<0.05). The results suggest that chitosan membrane combined with 1.0% TC may have beneficial effect on the regeneration of bone and cementum in intrabony periodontal defects.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2007 Apr 16


All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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