The effects of collagen membrane coated with PLGA on bone regeneration in rat calvarial defects

Young Song Kun, Jung Um Yoo, Won Jung Ui, Keun Lee Yong, Ho Choi Seong, Kwan Kim Chong

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate the effects of collagen membrane coated with PLGA on bone regeneration in rat calvarial defect. Five groups of 10 animals each received either collagen membrane coated with 0.5%, 1%, 3% concentration of PLGA. collagen membrane only or surgical control. Each group of animals was healed into 2 healing periods of 2(5 animals) and 8(5 animals)weeks and histologic and histomorphometric analysis were done. The results of the following study revealed that surgical implantation of collagen membranes coated with PLGA enhanced local bone formation at both 2 and 8 weeks independent of different PLGA concentrations. In conclusion, collagen membrane coated with PLGA shows a significant bone formation behavior irrespective of their concentration.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Jan 1

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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