The effects of physical activity and body fat mass on colorectal polyp recurrence in patients with previous colorectal cancer

Jihye Park, Jae Hyun Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y. Jeon, Tae Il Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We aimed to identify the effects of physical activity and body composition on colorectal polyp recurrence in patients with previous colorectal cancer. A total of 300 patients were selected randomly from the colorectal cancer survivor cohort of Severance Hospital (Seoul, Korea). Patients reported various recreational physical activities and received surveillance colonoscopy. Body composition was measured with a body composition analyzer. We compared patients who exercised for at least 1 hour/week (active) with those who exercised less frequently or not at all (sedentary). The active exercise group (n = 203) had a lower recurrence of advanced adenoma than the sedentary group (n = 97; 6.4% vs. 14.4%, P = 0.023). The prevalence of advanced adenoma recurrence decreased in an exercise dose-dependent manner (Ptrend = 0.019). In multivariate logistic analysis, the independent factors associated with advanced polyp recurrence were body fat mass [OR, 7.601; 95% confidence interval (CI), 1.583–36.485; P = 0.011] and active exercise (OR, 0.340; 95% CI, 0.143–0.809; P = 0.015). In Cox proportional hazards models, body fat mass (HR, 5.315; 95% CI, 1.173–24.083; P = 0.030) and active exercise (HR, 0.367; 95% CI, 0.162–0.833; P = 0.017) were the independent factors associated with cumulative advanced adenoma recurrence. In conclusion, exercising for at least 1 hour/week and low body fat mass were found to be related to lower rates of colorectal polyp recurrence in the surveillance of colorectal cancer survivors.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalCancer Prevention Research
Volume10
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

Bibliographical note

Funding Information:
This research was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1631020).

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The effects of physical activity and body fat mass on colorectal polyp recurrence in patients with previous colorectal cancer'. Together they form a unique fingerprint.

Cite this