The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis

A randomised controlled study

S. Y. Kim, B. N. Koo, C. S. Shin, M. Ban, KwangHyub Han, ManDeuk Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.

Original languageEnglish
Pages (from-to)580-587
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume123
Issue number4
DOIs
Publication statusPublished - 2016 Mar 1

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Uterine Artery Embolization
Adenomyosis
Leiomyoma
Dexamethasone
Pain
Fentanyl
Nausea
Vomiting
Patient-Controlled Analgesia
Inflammation
C-Reactive Protein
Hydrocortisone
Interleukin-6
Control Groups
Incidence
Korea
Leukocyte Count
Tertiary Care Centers
Analgesics
Neutrophils

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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title = "The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: A randomised controlled study",
abstract = "Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.",
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T1 - The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis

T2 - A randomised controlled study

AU - Kim, S. Y.

AU - Koo, B. N.

AU - Shin, C. S.

AU - Ban, M.

AU - Han, KwangHyub

AU - Kim, ManDeuk

PY - 2016/3/1

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N2 - Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.

AB - Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.

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