The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms

A study among patients with subcortical vascular cognitive impairments

Hee Jin Kim, Sue J. Kang, Changsoo Kim, Geon Ha Kim, Seun Jeon, Jong Min Lee, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Young Noh, Hanna Cho, Cindy W. Yoon, Juhee Chin, Jeffrey L. Cummings, Jae Hong Lee, Duk L. Na, Sang Won Seo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) such as lacunae or white matter hyperintensities (WMH), and amyloid burden affect NPS. We recruited 127 patients with subcortical vascular cognitive impairment who were assessed with brain magnetic resonance imaging, Pittsburgh compound-B (PiB) positron emission tomography and the neuropsychiatric inventory (NPI). To explore the association between lacunae, WMH, or PiB retention ratio and NPS, we performed multivariate regression analysis after controlling for possible confounders. Each additional lacuna, especially in the frontal region, was associated with higher odds of depression, apathy, aberrant motor behavior, nighttime behavior, appetite changes, and higher score of total NPI; larger WMH volume, especially in the frontal region, was associated with higher odds of apathy and higher score of total NPI. Furthermore, for the effects of lacunae or WMH on total NPI score we set Clinical Dementia Rating Sum of Boxes as the mediator. Greater PiB retention ratio was associated with higher odds of delusions and irritability. The SVD and amyloid pathologies did not show interactive effects on NPS. Our findings suggested that SVD and amyloid burden independently affected specific NPS.

Original languageEnglish
Pages (from-to)1913-1920
Number of pages8
JournalNeurobiology of Aging
Volume34
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

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Amyloid
Blood Vessels
Apathy
Equipment and Supplies
Dementia
Delusions
Appetite
Positron-Emission Tomography
Caregivers
Multivariate Analysis
Regression Analysis
Quality of Life
Magnetic Resonance Imaging
Depression
Pathology
Cognitive Dysfunction
White Matter
Brain
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Kim, Hee Jin ; Kang, Sue J. ; Kim, Changsoo ; Kim, Geon Ha ; Jeon, Seun ; Lee, Jong Min ; Oh, Seung Jun ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Noh, Young ; Cho, Hanna ; Yoon, Cindy W. ; Chin, Juhee ; Cummings, Jeffrey L. ; Lee, Jae Hong ; Na, Duk L. ; Seo, Sang Won. / The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms : A study among patients with subcortical vascular cognitive impairments. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 7. pp. 1913-1920.
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abstract = "Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) such as lacunae or white matter hyperintensities (WMH), and amyloid burden affect NPS. We recruited 127 patients with subcortical vascular cognitive impairment who were assessed with brain magnetic resonance imaging, Pittsburgh compound-B (PiB) positron emission tomography and the neuropsychiatric inventory (NPI). To explore the association between lacunae, WMH, or PiB retention ratio and NPS, we performed multivariate regression analysis after controlling for possible confounders. Each additional lacuna, especially in the frontal region, was associated with higher odds of depression, apathy, aberrant motor behavior, nighttime behavior, appetite changes, and higher score of total NPI; larger WMH volume, especially in the frontal region, was associated with higher odds of apathy and higher score of total NPI. Furthermore, for the effects of lacunae or WMH on total NPI score we set Clinical Dementia Rating Sum of Boxes as the mediator. Greater PiB retention ratio was associated with higher odds of delusions and irritability. The SVD and amyloid pathologies did not show interactive effects on NPS. Our findings suggested that SVD and amyloid burden independently affected specific NPS.",
author = "Kim, {Hee Jin} and Kang, {Sue J.} and Changsoo Kim and Kim, {Geon Ha} and Seun Jeon and Lee, {Jong Min} and Oh, {Seung Jun} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Young Noh and Hanna Cho and Yoon, {Cindy W.} and Juhee Chin and Cummings, {Jeffrey L.} and Lee, {Jae Hong} and Na, {Duk L.} and Seo, {Sang Won}",
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Kim, HJ, Kang, SJ, Kim, C, Kim, GH, Jeon, S, Lee, JM, Oh, SJ, Kim, JS, Choe, YS, Lee, KH, Noh, Y, Cho, H, Yoon, CW, Chin, J, Cummings, JL, Lee, JH, Na, DL & Seo, SW 2013, 'The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: A study among patients with subcortical vascular cognitive impairments', Neurobiology of Aging, vol. 34, no. 7, pp. 1913-1920. https://doi.org/10.1016/j.neurobiolaging.2013.01.002

The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms : A study among patients with subcortical vascular cognitive impairments. / Kim, Hee Jin; Kang, Sue J.; Kim, Changsoo; Kim, Geon Ha; Jeon, Seun; Lee, Jong Min; Oh, Seung Jun; Kim, Jae Seung; Choe, Yearn Seong; Lee, Kyung Han; Noh, Young; Cho, Hanna; Yoon, Cindy W.; Chin, Juhee; Cummings, Jeffrey L.; Lee, Jae Hong; Na, Duk L.; Seo, Sang Won.

In: Neurobiology of Aging, Vol. 34, No. 7, 01.07.2013, p. 1913-1920.

Research output: Contribution to journalArticle

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T1 - The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms

T2 - A study among patients with subcortical vascular cognitive impairments

AU - Kim, Hee Jin

AU - Kang, Sue J.

AU - Kim, Changsoo

AU - Kim, Geon Ha

AU - Jeon, Seun

AU - Lee, Jong Min

AU - Oh, Seung Jun

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Noh, Young

AU - Cho, Hanna

AU - Yoon, Cindy W.

AU - Chin, Juhee

AU - Cummings, Jeffrey L.

AU - Lee, Jae Hong

AU - Na, Duk L.

AU - Seo, Sang Won

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N2 - Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) such as lacunae or white matter hyperintensities (WMH), and amyloid burden affect NPS. We recruited 127 patients with subcortical vascular cognitive impairment who were assessed with brain magnetic resonance imaging, Pittsburgh compound-B (PiB) positron emission tomography and the neuropsychiatric inventory (NPI). To explore the association between lacunae, WMH, or PiB retention ratio and NPS, we performed multivariate regression analysis after controlling for possible confounders. Each additional lacuna, especially in the frontal region, was associated with higher odds of depression, apathy, aberrant motor behavior, nighttime behavior, appetite changes, and higher score of total NPI; larger WMH volume, especially in the frontal region, was associated with higher odds of apathy and higher score of total NPI. Furthermore, for the effects of lacunae or WMH on total NPI score we set Clinical Dementia Rating Sum of Boxes as the mediator. Greater PiB retention ratio was associated with higher odds of delusions and irritability. The SVD and amyloid pathologies did not show interactive effects on NPS. Our findings suggested that SVD and amyloid burden independently affected specific NPS.

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