The effects of statin use on the development of tuberculosis among patients with diabetes mellitus

Y. A. Kang, N. K. Choi, J. M. Seong, E. Y. Heo, B. K. Koo, S. S. Hwang, B. J. Park, J. J. Yim, C. H. Lee

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Abstract

OBJECTIVE: To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM). METHODS: This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded. RESULTS: Of 840 899 newly diagnosed type 2 DM patients, 281 842 (33.5%) patients were statin users and 559 057 (66.5%) were non-users. During the study period, 4052 individuals were diagnosed with TB; the estimated incidence of TB in our cohort was 251/100 000 patient-years (95%CI 243-258). In comparison to non-TB patients, statin users were less frequent among TB patients (19.2% vs. 33.6%). After adjustment for potential baseline confounders, statin use was not associated with the development of TB in DM patients (aHR 0.98; 95%CI 0.89-1.07). CONCLUSIONS: TB development among newly diagnosed type 2 DM was considerable, and statin use among these diabetics was not associated with a protective effect on TB incidence.

Original languageEnglish
Pages (from-to)717-724+i
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number6
DOIs
Publication statusPublished - 2014 Jun 1

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetes Mellitus
Tuberculosis
Type 2 Diabetes Mellitus
Incidence
Prescriptions
Cohort Studies
Retrospective Studies
Databases

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Kang, Y. A. ; Choi, N. K. ; Seong, J. M. ; Heo, E. Y. ; Koo, B. K. ; Hwang, S. S. ; Park, B. J. ; Yim, J. J. ; Lee, C. H. / The effects of statin use on the development of tuberculosis among patients with diabetes mellitus. In: International Journal of Tuberculosis and Lung Disease. 2014 ; Vol. 18, No. 6. pp. 717-724+i.
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abstract = "OBJECTIVE: To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM). METHODS: This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded. RESULTS: Of 840 899 newly diagnosed type 2 DM patients, 281 842 (33.5{\%}) patients were statin users and 559 057 (66.5{\%}) were non-users. During the study period, 4052 individuals were diagnosed with TB; the estimated incidence of TB in our cohort was 251/100 000 patient-years (95{\%}CI 243-258). In comparison to non-TB patients, statin users were less frequent among TB patients (19.2{\%} vs. 33.6{\%}). After adjustment for potential baseline confounders, statin use was not associated with the development of TB in DM patients (aHR 0.98; 95{\%}CI 0.89-1.07). CONCLUSIONS: TB development among newly diagnosed type 2 DM was considerable, and statin use among these diabetics was not associated with a protective effect on TB incidence.",
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The effects of statin use on the development of tuberculosis among patients with diabetes mellitus. / Kang, Y. A.; Choi, N. K.; Seong, J. M.; Heo, E. Y.; Koo, B. K.; Hwang, S. S.; Park, B. J.; Yim, J. J.; Lee, C. H.

In: International Journal of Tuberculosis and Lung Disease, Vol. 18, No. 6, 01.06.2014, p. 717-724+i.

Research output: Contribution to journalArticle

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T1 - The effects of statin use on the development of tuberculosis among patients with diabetes mellitus

AU - Kang, Y. A.

AU - Choi, N. K.

AU - Seong, J. M.

AU - Heo, E. Y.

AU - Koo, B. K.

AU - Hwang, S. S.

AU - Park, B. J.

AU - Yim, J. J.

AU - Lee, C. H.

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N2 - OBJECTIVE: To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM). METHODS: This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded. RESULTS: Of 840 899 newly diagnosed type 2 DM patients, 281 842 (33.5%) patients were statin users and 559 057 (66.5%) were non-users. During the study period, 4052 individuals were diagnosed with TB; the estimated incidence of TB in our cohort was 251/100 000 patient-years (95%CI 243-258). In comparison to non-TB patients, statin users were less frequent among TB patients (19.2% vs. 33.6%). After adjustment for potential baseline confounders, statin use was not associated with the development of TB in DM patients (aHR 0.98; 95%CI 0.89-1.07). CONCLUSIONS: TB development among newly diagnosed type 2 DM was considerable, and statin use among these diabetics was not associated with a protective effect on TB incidence.

AB - OBJECTIVE: To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM). METHODS: This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded. RESULTS: Of 840 899 newly diagnosed type 2 DM patients, 281 842 (33.5%) patients were statin users and 559 057 (66.5%) were non-users. During the study period, 4052 individuals were diagnosed with TB; the estimated incidence of TB in our cohort was 251/100 000 patient-years (95%CI 243-258). In comparison to non-TB patients, statin users were less frequent among TB patients (19.2% vs. 33.6%). After adjustment for potential baseline confounders, statin use was not associated with the development of TB in DM patients (aHR 0.98; 95%CI 0.89-1.07). CONCLUSIONS: TB development among newly diagnosed type 2 DM was considerable, and statin use among these diabetics was not associated with a protective effect on TB incidence.

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