The effects of strontium ions on epidermal permeability barrier

Hyun Jeong Kim, Min Jung Kim, Se Kyoo Jeong, Ki Ju Choi, Jeong Taek Seo, Eung Ho Choi, Sung Ku Ahn, Sung Hun Lee

Research output: Contribution to journalArticle

Abstract

Background: Several ions, such as calcium or magnesium ions, are reported to have regulatory effects on epidermal permeability barrier homeostasis. Recently, it has been suggested that strontium ion can play a substitutive role for calcium ion in various cellular reactions. Objective: This study was conducted to investigate the effects of strontium ion, either alone or in combination with calcium or magnesium ions, on epidermal permeability barrier homeostasis. Methods: Female hairless mice were used to study the effects of various ions on epidermal permeability barrier recovery. Calcium chloride solution, magnesium chloride solution or strontium chloride solution were topically applied to barrier-disrupted skin, either alone or simultaneously. Change of transepidermal water loss, which represents permeability barrier function, was measured by TEWameter and morphological change was also observed by light and electron microscopy. Results: Topical application of strontium chloride solution accelerated permeability barrier recovery rate, compared with vehicle-applied skin. Magnesium chloride solution also accelerated barrier recovery rate, as reported in previous studies. Interestingly, simultaneous application of strontium and calcium ions significantly accelerated barrier recovery rate, compared to application of strontium or calcium ion alone. Nile red staining confirmed the increased neutral lipid deposition in strontium ion applied skin. Electron microscopic observation also revealed an increased lamellar body secretion in strontium ion applied skin. Conclusion: Strontium ion can play a regulatory role in epidermal permeability barrier homeostasis due to, at least in part, its competitive action on calcium ion for the same ion channel.

Original languageEnglish
Pages (from-to)1309-1316
Number of pages8
JournalKorean Journal of Dermatology
Volume44
Issue number11
Publication statusPublished - 2006 Nov 1

Fingerprint

Strontium
Permeability
Ions
Calcium
Skin
Magnesium Chloride
Homeostasis
Magnesium
Hairless Mouse
Calcium Chloride
Ion Channels
Electron Microscopy

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, H. J., Kim, M. J., Jeong, S. K., Choi, K. J., Seo, J. T., Choi, E. H., ... Lee, S. H. (2006). The effects of strontium ions on epidermal permeability barrier. Korean Journal of Dermatology, 44(11), 1309-1316.
Kim, Hyun Jeong ; Kim, Min Jung ; Jeong, Se Kyoo ; Choi, Ki Ju ; Seo, Jeong Taek ; Choi, Eung Ho ; Ahn, Sung Ku ; Lee, Sung Hun. / The effects of strontium ions on epidermal permeability barrier. In: Korean Journal of Dermatology. 2006 ; Vol. 44, No. 11. pp. 1309-1316.
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abstract = "Background: Several ions, such as calcium or magnesium ions, are reported to have regulatory effects on epidermal permeability barrier homeostasis. Recently, it has been suggested that strontium ion can play a substitutive role for calcium ion in various cellular reactions. Objective: This study was conducted to investigate the effects of strontium ion, either alone or in combination with calcium or magnesium ions, on epidermal permeability barrier homeostasis. Methods: Female hairless mice were used to study the effects of various ions on epidermal permeability barrier recovery. Calcium chloride solution, magnesium chloride solution or strontium chloride solution were topically applied to barrier-disrupted skin, either alone or simultaneously. Change of transepidermal water loss, which represents permeability barrier function, was measured by TEWameter and morphological change was also observed by light and electron microscopy. Results: Topical application of strontium chloride solution accelerated permeability barrier recovery rate, compared with vehicle-applied skin. Magnesium chloride solution also accelerated barrier recovery rate, as reported in previous studies. Interestingly, simultaneous application of strontium and calcium ions significantly accelerated barrier recovery rate, compared to application of strontium or calcium ion alone. Nile red staining confirmed the increased neutral lipid deposition in strontium ion applied skin. Electron microscopic observation also revealed an increased lamellar body secretion in strontium ion applied skin. Conclusion: Strontium ion can play a regulatory role in epidermal permeability barrier homeostasis due to, at least in part, its competitive action on calcium ion for the same ion channel.",
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Kim, HJ, Kim, MJ, Jeong, SK, Choi, KJ, Seo, JT, Choi, EH, Ahn, SK & Lee, SH 2006, 'The effects of strontium ions on epidermal permeability barrier', Korean Journal of Dermatology, vol. 44, no. 11, pp. 1309-1316.

The effects of strontium ions on epidermal permeability barrier. / Kim, Hyun Jeong; Kim, Min Jung; Jeong, Se Kyoo; Choi, Ki Ju; Seo, Jeong Taek; Choi, Eung Ho; Ahn, Sung Ku; Lee, Sung Hun.

In: Korean Journal of Dermatology, Vol. 44, No. 11, 01.11.2006, p. 1309-1316.

Research output: Contribution to journalArticle

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AU - Kim, Hyun Jeong

AU - Kim, Min Jung

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AU - Ahn, Sung Ku

AU - Lee, Sung Hun

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N2 - Background: Several ions, such as calcium or magnesium ions, are reported to have regulatory effects on epidermal permeability barrier homeostasis. Recently, it has been suggested that strontium ion can play a substitutive role for calcium ion in various cellular reactions. Objective: This study was conducted to investigate the effects of strontium ion, either alone or in combination with calcium or magnesium ions, on epidermal permeability barrier homeostasis. Methods: Female hairless mice were used to study the effects of various ions on epidermal permeability barrier recovery. Calcium chloride solution, magnesium chloride solution or strontium chloride solution were topically applied to barrier-disrupted skin, either alone or simultaneously. Change of transepidermal water loss, which represents permeability barrier function, was measured by TEWameter and morphological change was also observed by light and electron microscopy. Results: Topical application of strontium chloride solution accelerated permeability barrier recovery rate, compared with vehicle-applied skin. Magnesium chloride solution also accelerated barrier recovery rate, as reported in previous studies. Interestingly, simultaneous application of strontium and calcium ions significantly accelerated barrier recovery rate, compared to application of strontium or calcium ion alone. Nile red staining confirmed the increased neutral lipid deposition in strontium ion applied skin. Electron microscopic observation also revealed an increased lamellar body secretion in strontium ion applied skin. Conclusion: Strontium ion can play a regulatory role in epidermal permeability barrier homeostasis due to, at least in part, its competitive action on calcium ion for the same ion channel.

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Kim HJ, Kim MJ, Jeong SK, Choi KJ, Seo JT, Choi EH et al. The effects of strontium ions on epidermal permeability barrier. Korean Journal of Dermatology. 2006 Nov 1;44(11):1309-1316.