Background: Retinaldehyde is one of the major members of the retinoid family, which has potential skin rejuvenating effects on photoaged skin and has a good safety profile. Aims: The study aimed to evaluate the efficacy and safety of multilamellar vesicle containing retinaldehyde (MLV-RAL) 0.05% and 0.1% used to treat photoaged skin. Patients and methods: A randomized, prospective, investigator-blinded, split-face comparison study was conducted. We enrolled 23 Korean volunteers who applied MLV-RAL 0.05%/0.1% cream on one randomized side of their face and retinol 0.05%/0.1% cream on the opposite side. Wrinkle depth on both crow's feet was assessed by the Antera 3D system. Skin hydration, elasticity, facial curved length, and dermal density were also evaluated. Results: After an 8-week application, all objective parameters, including wrinkle depth, were significantly improved in both MLV-RAL 0.05%/0.1% and retinol 0.05%/0.1% treated sides. Compared with the retinol-treated side, MLV-RAL-treated side showed a significant improvement of objective assessments except for dermal density. Additionally, there was no adverse event associated with the use of either MLV-RAL 0.05%/0.1% or retinol 0.05%/0.1% cream. Conclusion: The application of MLV-RAL 0.05%/0.1% cream improved wrinkle, facial contour, and biophysical parameters associated with skin aging.
|Number of pages||6|
|Journal||Journal of Cosmetic Dermatology|
|Publication status||Published - 2021 Sept|
Bibliographical noteFunding Information:
The study product (Dr Different Vita-A Cream® and Dr Different Vita-A Cream Forte®, Dareun Cosmetics Co, Seoul, Korea) was provided by Dareun Cosmetics. However, Dareun Cosmetics had no role in the study design, implementation, data collection, data analysis, data interpretation, manuscript preparation, manuscript review, or manuscript approval.
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