The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma

Semi Park, Jeong Youp Park, Moon Jae Chung, Jae Bock Chung, Seung Woo Park, Kwang Hyub Han, Si Young Song, Seungmin Bang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Obstructive jaundice in patients with hepatocellular carcinoma (HCC) is uncommon (0.5--13%). Unlike other causes of obstructive jaundice, the role of endoscopic intervention in obstructive jaundice complicated by HCC has not been clearly defined. The aim of this study was to evaluate the clinical characteristics of obstructive jaundice caused by HCC and predictive factors for successful endoscopic intervention. Materials and Methods: From 1999 to 2009, 54 patients with HCC who underwent endoscopic intervention to relieve obstructive jaundice were included. We defined endoscopic intervention as a clinical success when the obstructive jaundice was relieved within 4 weeks. Results: Clinical success was achieved in 23 patients (42.6%). Patients in the clinical success group showed better Child-Pugh liver function (C-P grade A or B/C; 17/6 vs. 8/20), lower total bilirubin levels (8.1±5.3 mg/dL vs. 23.1±10.4 mg/dL) prior to the treatment, and no history of alcohol consumption. The only factor predictive of clinical success by multivariate analysis was low total bilirubin level at the time of endoscopic intervention, regardless of history of alcohol consumption [odds ratio 1.223 (95% confidence interval, 1.071-1.396), p=0.003]. The cut-off value of pre-endoscopic treatment total bilirubin level was 12.8 mg/dL for predicting the clinical prognosis. Median survival after endoscopic intervention in the clinical success group was notably longer than that in the clinical failure group (5.6 months vs. 1.5 months, p≤0.001). Conclusion: Before endoscopic intervention, liver function, especially total bilirubin level, should be checked to achieve the best clinical outcome. Endoscopic intervention can be helpful to relieve jaundice in well selected patients with HCC.

Original languageEnglish
Pages (from-to)1267-1272
Number of pages6
JournalYonsei medical journal
Volume55
Issue number5
DOIs
Publication statusPublished - 2014 Sep

Fingerprint

Obstructive Jaundice
Hepatocellular Carcinoma
Bilirubin
Alcohol Drinking
Liver
Jaundice
Multivariate Analysis
Odds Ratio
Confidence Intervals
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Semi ; Park, Jeong Youp ; Chung, Moon Jae ; Chung, Jae Bock ; Park, Seung Woo ; Han, Kwang Hyub ; Song, Si Young ; Bang, Seungmin. / The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma. In: Yonsei medical journal. 2014 ; Vol. 55, No. 5. pp. 1267-1272.
@article{db76053cf22648628065a53cd8535769,
title = "The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma",
abstract = "Purpose: Obstructive jaundice in patients with hepatocellular carcinoma (HCC) is uncommon (0.5--13{\%}). Unlike other causes of obstructive jaundice, the role of endoscopic intervention in obstructive jaundice complicated by HCC has not been clearly defined. The aim of this study was to evaluate the clinical characteristics of obstructive jaundice caused by HCC and predictive factors for successful endoscopic intervention. Materials and Methods: From 1999 to 2009, 54 patients with HCC who underwent endoscopic intervention to relieve obstructive jaundice were included. We defined endoscopic intervention as a clinical success when the obstructive jaundice was relieved within 4 weeks. Results: Clinical success was achieved in 23 patients (42.6{\%}). Patients in the clinical success group showed better Child-Pugh liver function (C-P grade A or B/C; 17/6 vs. 8/20), lower total bilirubin levels (8.1±5.3 mg/dL vs. 23.1±10.4 mg/dL) prior to the treatment, and no history of alcohol consumption. The only factor predictive of clinical success by multivariate analysis was low total bilirubin level at the time of endoscopic intervention, regardless of history of alcohol consumption [odds ratio 1.223 (95{\%} confidence interval, 1.071-1.396), p=0.003]. The cut-off value of pre-endoscopic treatment total bilirubin level was 12.8 mg/dL for predicting the clinical prognosis. Median survival after endoscopic intervention in the clinical success group was notably longer than that in the clinical failure group (5.6 months vs. 1.5 months, p≤0.001). Conclusion: Before endoscopic intervention, liver function, especially total bilirubin level, should be checked to achieve the best clinical outcome. Endoscopic intervention can be helpful to relieve jaundice in well selected patients with HCC.",
author = "Semi Park and Park, {Jeong Youp} and Chung, {Moon Jae} and Chung, {Jae Bock} and Park, {Seung Woo} and Han, {Kwang Hyub} and Song, {Si Young} and Seungmin Bang",
year = "2014",
month = "9",
doi = "10.3349/ymj.2014.55.5.1267",
language = "English",
volume = "55",
pages = "1267--1272",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "5",

}

Park, S, Park, JY, Chung, MJ, Chung, JB, Park, SW, Han, KH, Song, SY & Bang, S 2014, 'The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma', Yonsei medical journal, vol. 55, no. 5, pp. 1267-1272. https://doi.org/10.3349/ymj.2014.55.5.1267

The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma. / Park, Semi; Park, Jeong Youp; Chung, Moon Jae; Chung, Jae Bock; Park, Seung Woo; Han, Kwang Hyub; Song, Si Young; Bang, Seungmin.

In: Yonsei medical journal, Vol. 55, No. 5, 09.2014, p. 1267-1272.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma

AU - Park, Semi

AU - Park, Jeong Youp

AU - Chung, Moon Jae

AU - Chung, Jae Bock

AU - Park, Seung Woo

AU - Han, Kwang Hyub

AU - Song, Si Young

AU - Bang, Seungmin

PY - 2014/9

Y1 - 2014/9

N2 - Purpose: Obstructive jaundice in patients with hepatocellular carcinoma (HCC) is uncommon (0.5--13%). Unlike other causes of obstructive jaundice, the role of endoscopic intervention in obstructive jaundice complicated by HCC has not been clearly defined. The aim of this study was to evaluate the clinical characteristics of obstructive jaundice caused by HCC and predictive factors for successful endoscopic intervention. Materials and Methods: From 1999 to 2009, 54 patients with HCC who underwent endoscopic intervention to relieve obstructive jaundice were included. We defined endoscopic intervention as a clinical success when the obstructive jaundice was relieved within 4 weeks. Results: Clinical success was achieved in 23 patients (42.6%). Patients in the clinical success group showed better Child-Pugh liver function (C-P grade A or B/C; 17/6 vs. 8/20), lower total bilirubin levels (8.1±5.3 mg/dL vs. 23.1±10.4 mg/dL) prior to the treatment, and no history of alcohol consumption. The only factor predictive of clinical success by multivariate analysis was low total bilirubin level at the time of endoscopic intervention, regardless of history of alcohol consumption [odds ratio 1.223 (95% confidence interval, 1.071-1.396), p=0.003]. The cut-off value of pre-endoscopic treatment total bilirubin level was 12.8 mg/dL for predicting the clinical prognosis. Median survival after endoscopic intervention in the clinical success group was notably longer than that in the clinical failure group (5.6 months vs. 1.5 months, p≤0.001). Conclusion: Before endoscopic intervention, liver function, especially total bilirubin level, should be checked to achieve the best clinical outcome. Endoscopic intervention can be helpful to relieve jaundice in well selected patients with HCC.

AB - Purpose: Obstructive jaundice in patients with hepatocellular carcinoma (HCC) is uncommon (0.5--13%). Unlike other causes of obstructive jaundice, the role of endoscopic intervention in obstructive jaundice complicated by HCC has not been clearly defined. The aim of this study was to evaluate the clinical characteristics of obstructive jaundice caused by HCC and predictive factors for successful endoscopic intervention. Materials and Methods: From 1999 to 2009, 54 patients with HCC who underwent endoscopic intervention to relieve obstructive jaundice were included. We defined endoscopic intervention as a clinical success when the obstructive jaundice was relieved within 4 weeks. Results: Clinical success was achieved in 23 patients (42.6%). Patients in the clinical success group showed better Child-Pugh liver function (C-P grade A or B/C; 17/6 vs. 8/20), lower total bilirubin levels (8.1±5.3 mg/dL vs. 23.1±10.4 mg/dL) prior to the treatment, and no history of alcohol consumption. The only factor predictive of clinical success by multivariate analysis was low total bilirubin level at the time of endoscopic intervention, regardless of history of alcohol consumption [odds ratio 1.223 (95% confidence interval, 1.071-1.396), p=0.003]. The cut-off value of pre-endoscopic treatment total bilirubin level was 12.8 mg/dL for predicting the clinical prognosis. Median survival after endoscopic intervention in the clinical success group was notably longer than that in the clinical failure group (5.6 months vs. 1.5 months, p≤0.001). Conclusion: Before endoscopic intervention, liver function, especially total bilirubin level, should be checked to achieve the best clinical outcome. Endoscopic intervention can be helpful to relieve jaundice in well selected patients with HCC.

UR - http://www.scopus.com/inward/record.url?scp=84904751233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904751233&partnerID=8YFLogxK

U2 - 10.3349/ymj.2014.55.5.1267

DO - 10.3349/ymj.2014.55.5.1267

M3 - Article

C2 - 25048484

AN - SCOPUS:84904751233

VL - 55

SP - 1267

EP - 1272

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 5

ER -