The expression of metabolism-related proteins in phyllodes tumors

Ji Eun Kwon, Woo Hee Jung, Ja Seung Koo

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to investigate the association between the expression of hypoxia-inducible factor (HIF)-1α, insulin-like growth factor (IGF)-1, glucose transporter 1 (Glut-1), carbonic anhydrase IX (CAIX), and monocarboxylate transporter (MCT)4, which are metabolism-related proteins in phyllodes tumors (PTs), and clinicopathologic factors and its implication. We used tissue microarrays to analyze 207 PTs and performed immunohistochemical staining against the glycolysis-related molecules HIF-1α, IGF-1, Glut-1, CAIX, and MCT4. We then compared the immunohistochemical results and clinicopathologic parameters. The expressions of HIF-1α, Glut-1, CAIX, and MCT4 in the stromal component of PTs increased (P = 0.019, P < 0.001, P = 0.045, and P < 0.001, respectively) with increasing tumor grade. According to univariate analysis, factors associated with shorter disease-free survival were Glut-1 expression (P = 0.001) and MCT4 expression (P < 0.001) in the stromal component, and the factors associated with shorter overall survival were IGF-1 expression (P = 0.012), Glut-1 expression (P < 0.001), CAIX expression (P = 0.039), and MCT4 expression (P < 0.001) in the stromal component. Our investigation of stromal expression of the metabolism-related proteins HIF-1α, IGF-1, Glut-1, CAIX, and MCT4 revealed that, as the PT grade increased, the stromal expression of HIF-1α, Glut-1, CAIX, and MCT4 significantly increased. This result suggested that increasing PT grade is associated with increased glycolysis in the stromal component.

Original languageEnglish
Pages (from-to)115-124
Number of pages10
JournalTumor Biology
Volume34
Issue number1
DOIs
Publication statusPublished - 2013 Feb 1

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Phyllodes Tumor
Facilitative Glucose Transport Proteins
Hypoxia-Inducible Factor 1
Somatomedins
Proteins
Glycolysis
Tissue Array Analysis
Statistical Factor Analysis
Disease-Free Survival
Carbonic Anhydrase IX
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Kwon, Ji Eun ; Jung, Woo Hee ; Koo, Ja Seung. / The expression of metabolism-related proteins in phyllodes tumors. In: Tumor Biology. 2013 ; Vol. 34, No. 1. pp. 115-124.
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The expression of metabolism-related proteins in phyllodes tumors. / Kwon, Ji Eun; Jung, Woo Hee; Koo, Ja Seung.

In: Tumor Biology, Vol. 34, No. 1, 01.02.2013, p. 115-124.

Research output: Contribution to journalArticle

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