The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity

Jong Suep Baek, Ji Ho Lim, Jae Woo So, Jae Il Kim, Tae Wan Lee, Sung Joo Hwang, Sang Chul Shin, Soo Jin Kim, Cheong Weon Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80® and plasticizer of diethyl phthalate were combined with citalopram-ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80® and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalJournal of Pharmaceutical Investigation
Volume42
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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