The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity

Jong Suep Baek, Ji Ho Lim, Jae Woo So, Jae Il Kim, Tae Wan Lee, Sung Joo Hwang, Sang Chul Shin, Soo Jin Kim, Cheong Weon Cho

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80® and plasticizer of diethyl phthalate were combined with citalopram-ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80® and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalJournal of Pharmaceutical Investigation
Volume42
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Citalopram
Feasibility Studies
Drug Delivery Systems
Hydrophobic and Hydrophilic Interactions
Antidepressive Agents
Propylene Glycol
Polysorbates
Oleic Acid
Gels
Plasticizers
Skin
Surface-Active Agents
Oral Administration
Stomach
Venlafaxine Hydrochloride

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Baek, Jong Suep ; Lim, Ji Ho ; So, Jae Woo ; Kim, Jae Il ; Lee, Tae Wan ; Hwang, Sung Joo ; Shin, Sang Chul ; Kim, Soo Jin ; Cho, Cheong Weon. / The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity. In: Journal of Pharmaceutical Investigation. 2012 ; Vol. 42, No. 3. pp. 109-114.
@article{3b55b4cdfdf04ab3a5c5e2244fda0c88,
title = "The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity",
abstract = "The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80{\circledR} and plasticizer of diethyl phthalate were combined with citalopram-ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80{\circledR} and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.",
author = "Baek, {Jong Suep} and Lim, {Ji Ho} and So, {Jae Woo} and Kim, {Jae Il} and Lee, {Tae Wan} and Hwang, {Sung Joo} and Shin, {Sang Chul} and Kim, {Soo Jin} and Cho, {Cheong Weon}",
year = "2012",
month = "6",
day = "1",
doi = "10.1007/s40005-012-0017-4",
language = "English",
volume = "42",
pages = "109--114",
journal = "Journal of Pharmaceutical Investigation",
issn = "2093-5552",
publisher = "Springer Netherlands",
number = "3",

}

The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity. / Baek, Jong Suep; Lim, Ji Ho; So, Jae Woo; Kim, Jae Il; Lee, Tae Wan; Hwang, Sung Joo; Shin, Sang Chul; Kim, Soo Jin; Cho, Cheong Weon.

In: Journal of Pharmaceutical Investigation, Vol. 42, No. 3, 01.06.2012, p. 109-114.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity

AU - Baek, Jong Suep

AU - Lim, Ji Ho

AU - So, Jae Woo

AU - Kim, Jae Il

AU - Lee, Tae Wan

AU - Hwang, Sung Joo

AU - Shin, Sang Chul

AU - Kim, Soo Jin

AU - Cho, Cheong Weon

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80® and plasticizer of diethyl phthalate were combined with citalopram-ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80® and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.

AB - The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80® and plasticizer of diethyl phthalate were combined with citalopram-ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80® and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.

UR - http://www.scopus.com/inward/record.url?scp=84870316108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870316108&partnerID=8YFLogxK

U2 - 10.1007/s40005-012-0017-4

DO - 10.1007/s40005-012-0017-4

M3 - Article

AN - SCOPUS:84870316108

VL - 42

SP - 109

EP - 114

JO - Journal of Pharmaceutical Investigation

JF - Journal of Pharmaceutical Investigation

SN - 2093-5552

IS - 3

ER -