The flower extract of abelmoschus manihot (linn.) increases cyclin d1 expression and activates cell proliferation

Yea In Park, Yeo Eun Cha, Minsu Jang, Rackhyun Park, Sim Namkoong, Jongbock Kwak, Ik Soon Jang, Junsoo Park

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Abelmoschus manihot (Linn.) is a medicinal herbal plant that is commonly used to treat chronic kidney disease and hepatitis. However, its effect on cell proliferation has not been clearly revealed. In this report, we sought to determine the effect of the flower extract of A. manihot (FA) on cell proliferation. Based on our findings, FA increased the proliferation of human diploid fibroblast (HDF) and HEK293 cells. Through cell cycle analysis, FA was found to increase the number of HDF cells in the S phase and G2/M phase. FA also increased the expression of cyclin D1 and enhanced the migration of HDF cells. By administering FA to HDF cells with 30 passages, a decrease in the number of senescence-Associated B galactosidase-positive cells was observed, thereby indicating that FA can ameliorate cellular senescence. Collectively, our findings indicate that FA increases cyclin D1 expression and regulates cell proliferation.

Original languageEnglish
Pages (from-to)1044-1050
Number of pages7
JournalJournal of microbiology and biotechnology
Issue number7
Publication statusPublished - 2020 Jul

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (2019R1A2C1006511).

Publisher Copyright:
© 2020 Korean Society for Microbiology and Biotechnology. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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