The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: Do the diagnostic criteria for preterm labor need to be changed?

Sun Min Kim, Roberto Romero, Joon Ho Lee, Seung Mi Lee, Chan Wook Park, Joong Shin Park, Bo Hyun Yoon

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: The objective of this study was to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm increased uterine contractility with intact membranes but without cervical change. Methods: Amniocentesis was performed in 132 patients with regular uterine contractions and intact membranes without cervical change. Amniotic fluid was cultured for bacteria and mycoplasmas and assayed for matrix metalloproteinase-8 (MMP-8). Intra-amniotic inflammation was defined as an elevated amniotic fluid MMP-8 concentration (>23-ng/mL). Results: (1) Intra-amniotic inflammation was present in 12.1% (16/132); (2) Culture-proven intra-amniotic infection was diagnosed in 3% (4/132) of patients without demonstrable cervical change on admission or during the period of observation; and (3) Patients with intra-amniotic inflammation had significantly higher rates of preterm delivery and adverse outcomes, and shorter amniocentesis-to-delivery intervals than those without intra-amniotic inflammation (P < 0.05 for each). Adverse outcomes included chorioamnionitis, funisitis, and neonatal death. Conclusion: Intra-amniotic inflammation was present in 12% of patients with regular uterine contractions without cervical change, while culture-proven intra-amniotic infection was present in 3%. The presence of intra-amniotic inflammation was a significant risk factor for adverse neonatal outcomes. These observations question whether cervical changes should be required for the diagnosis of preterm labor, because patients without modifications in cervical status on admission or during a period of observation are at risk for adverse pregnancy outcomes.

Original languageEnglish
Pages (from-to)1212-1221
Number of pages10
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

Fingerprint

Premature Obstetric Labor
Inflammation
Matrix Metalloproteinase 8
Chorioamnionitis
Uterine Contraction
Amniocentesis
Amniotic Fluid
Observation
Membranes
Mycoplasma
Pregnancy Outcome
Infection
Bacteria

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

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title = "The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: Do the diagnostic criteria for preterm labor need to be changed?",
abstract = "Objective: The objective of this study was to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm increased uterine contractility with intact membranes but without cervical change. Methods: Amniocentesis was performed in 132 patients with regular uterine contractions and intact membranes without cervical change. Amniotic fluid was cultured for bacteria and mycoplasmas and assayed for matrix metalloproteinase-8 (MMP-8). Intra-amniotic inflammation was defined as an elevated amniotic fluid MMP-8 concentration (>23-ng/mL). Results: (1) Intra-amniotic inflammation was present in 12.1{\%} (16/132); (2) Culture-proven intra-amniotic infection was diagnosed in 3{\%} (4/132) of patients without demonstrable cervical change on admission or during the period of observation; and (3) Patients with intra-amniotic inflammation had significantly higher rates of preterm delivery and adverse outcomes, and shorter amniocentesis-to-delivery intervals than those without intra-amniotic inflammation (P < 0.05 for each). Adverse outcomes included chorioamnionitis, funisitis, and neonatal death. Conclusion: Intra-amniotic inflammation was present in 12{\%} of patients with regular uterine contractions without cervical change, while culture-proven intra-amniotic infection was present in 3{\%}. The presence of intra-amniotic inflammation was a significant risk factor for adverse neonatal outcomes. These observations question whether cervical changes should be required for the diagnosis of preterm labor, because patients without modifications in cervical status on admission or during a period of observation are at risk for adverse pregnancy outcomes.",
author = "Kim, {Sun Min} and Roberto Romero and Lee, {Joon Ho} and Lee, {Seung Mi} and Park, {Chan Wook} and Park, {Joong Shin} and Yoon, {Bo Hyun}",
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The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change : Do the diagnostic criteria for preterm labor need to be changed? / Kim, Sun Min; Romero, Roberto; Lee, Joon Ho; Lee, Seung Mi; Park, Chan Wook; Park, Joong Shin; Yoon, Bo Hyun.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 25, No. 8, 01.08.2012, p. 1212-1221.

Research output: Contribution to journalArticle

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T1 - The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change

T2 - Do the diagnostic criteria for preterm labor need to be changed?

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AU - Romero, Roberto

AU - Lee, Joon Ho

AU - Lee, Seung Mi

AU - Park, Chan Wook

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AU - Yoon, Bo Hyun

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N2 - Objective: The objective of this study was to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm increased uterine contractility with intact membranes but without cervical change. Methods: Amniocentesis was performed in 132 patients with regular uterine contractions and intact membranes without cervical change. Amniotic fluid was cultured for bacteria and mycoplasmas and assayed for matrix metalloproteinase-8 (MMP-8). Intra-amniotic inflammation was defined as an elevated amniotic fluid MMP-8 concentration (>23-ng/mL). Results: (1) Intra-amniotic inflammation was present in 12.1% (16/132); (2) Culture-proven intra-amniotic infection was diagnosed in 3% (4/132) of patients without demonstrable cervical change on admission or during the period of observation; and (3) Patients with intra-amniotic inflammation had significantly higher rates of preterm delivery and adverse outcomes, and shorter amniocentesis-to-delivery intervals than those without intra-amniotic inflammation (P < 0.05 for each). Adverse outcomes included chorioamnionitis, funisitis, and neonatal death. Conclusion: Intra-amniotic inflammation was present in 12% of patients with regular uterine contractions without cervical change, while culture-proven intra-amniotic infection was present in 3%. The presence of intra-amniotic inflammation was a significant risk factor for adverse neonatal outcomes. These observations question whether cervical changes should be required for the diagnosis of preterm labor, because patients without modifications in cervical status on admission or during a period of observation are at risk for adverse pregnancy outcomes.

AB - Objective: The objective of this study was to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm increased uterine contractility with intact membranes but without cervical change. Methods: Amniocentesis was performed in 132 patients with regular uterine contractions and intact membranes without cervical change. Amniotic fluid was cultured for bacteria and mycoplasmas and assayed for matrix metalloproteinase-8 (MMP-8). Intra-amniotic inflammation was defined as an elevated amniotic fluid MMP-8 concentration (>23-ng/mL). Results: (1) Intra-amniotic inflammation was present in 12.1% (16/132); (2) Culture-proven intra-amniotic infection was diagnosed in 3% (4/132) of patients without demonstrable cervical change on admission or during the period of observation; and (3) Patients with intra-amniotic inflammation had significantly higher rates of preterm delivery and adverse outcomes, and shorter amniocentesis-to-delivery intervals than those without intra-amniotic inflammation (P < 0.05 for each). Adverse outcomes included chorioamnionitis, funisitis, and neonatal death. Conclusion: Intra-amniotic inflammation was present in 12% of patients with regular uterine contractions without cervical change, while culture-proven intra-amniotic infection was present in 3%. The presence of intra-amniotic inflammation was a significant risk factor for adverse neonatal outcomes. These observations question whether cervical changes should be required for the diagnosis of preterm labor, because patients without modifications in cervical status on admission or during a period of observation are at risk for adverse pregnancy outcomes.

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