The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans

Myon Hee Lee, Byungchan Ahn, In Soon Choi, Hyeon-Sook Koo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalFEBS Letters
Volume522
Issue number1-3
DOIs
Publication statusPublished - 2002 Jul 3

Fingerprint

Caenorhabditis elegans Proteins
Cockayne Syndrome
Gene expression
Genes
Caenorhabditis elegans
Phenotype
Gene Expression
Germ Cells
Cell proliferation
Ultraviolet radiation
Exons
Repair
Nucleotides
Cells
RNA
Apoptosis
RNA Interference
DNA Repair
Open Reading Frames
Reproduction

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Lee, Myon Hee ; Ahn, Byungchan ; Choi, In Soon ; Koo, Hyeon-Sook. / The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans. In: FEBS Letters. 2002 ; Vol. 522, No. 1-3. pp. 47-51.
@article{f1db67859dfb441bb5414b0fe0f62486,
title = "The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans",
abstract = "The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.",
author = "Lee, {Myon Hee} and Byungchan Ahn and Choi, {In Soon} and Hyeon-Sook Koo",
year = "2002",
month = "7",
day = "3",
doi = "10.1016/S0014-5793(02)02880-6",
language = "English",
volume = "522",
pages = "47--51",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1-3",

}

The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans. / Lee, Myon Hee; Ahn, Byungchan; Choi, In Soon; Koo, Hyeon-Sook.

In: FEBS Letters, Vol. 522, No. 1-3, 03.07.2002, p. 47-51.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans

AU - Lee, Myon Hee

AU - Ahn, Byungchan

AU - Choi, In Soon

AU - Koo, Hyeon-Sook

PY - 2002/7/3

Y1 - 2002/7/3

N2 - The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.

AB - The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.

UR - http://www.scopus.com/inward/record.url?scp=0037014596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037014596&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(02)02880-6

DO - 10.1016/S0014-5793(02)02880-6

M3 - Article

C2 - 12095617

AN - SCOPUS:0037014596

VL - 522

SP - 47

EP - 51

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1-3

ER -