The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans

Myon Hee Lee, Byungchan Ahn, In Soon Choi, Hyeon Sook Koo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalFEBS Letters
Volume522
Issue number1-3
DOIs
Publication statusPublished - 2002 Jul 3

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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