The growth inhibitiory effect of new pyrrolo[1,2-α]benzimidazole derivatives on human gastric cancer cells

Soo Kie Kim, Chan Mug Ahn, Sun Ju Choi, Yoon Sun Park, Hyun Chul Cho, Choon Myung Koh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the course of screening synthetic compounds to inhibit tumor cell growth, pyrrolo[1,2-α] benzimidazole (PBI), an intermediate of azamitosene, was found to inhibit a proliferation of gastric cancer cell lines. Despite a potential cytotoxic activity against solid tumor cells as opposed to that against rapidly-doubled leukemic cells, there has been no report on the inhibition of gastric cancer cell line by PBI and its' derivatives. The present experiment was designed to determine if PBI derivatives can effectively inhibit the cellular proliferation of gastric cancer cells by using in vitro as well as in vivo chemosensitivity system (MTT assay, clonogenic assay and human tumor xenografted assay). Of the tested PBI derivatives, PBI (18) and PBI (20), displayed the effective growth inhibition of cultured gastric cancer cells or even in the xenografted nude mouse model.

Original languageEnglish
Pages (from-to)410-413
Number of pages4
JournalArchives of pharmacal research
Volume20
Issue number5
DOIs
Publication statusPublished - 1997 Oct

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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