The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR

Bum Joon Park, Jin Wook Kang, Sang Won Lee, So Jung Choi, Young Kee Shin, Young Ha Ahn, Yun Hee Choi, Dongho Choi, Kwang Soo Lee, Sunghoon Kim

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

p18 was first identified as a factor associated with a macromolecular tRNA synthetase complex. Here we describe the mouse p18 loss-of-function phenotype and a role for p18 in the DNA damage response. Inactivation of both p18 alleles caused embryonic lethality, while heterozygous mice showed high susceptibility to spontaneous tumors. p18 was induced and translocated to the nucleus in response to DNA damage. Expression of p18 resulted in elevated p53 levels, while p18 depletion blocked p53 induction. p18 directly interacted with ATM/ATR in response to DNA damage. The activity of ATM was dependent on the level of p18, suggesting the requirement of p18 for the activation of ATM. Low p18 expression was frequently observed in different human cancer cell lines and tissues. These results suggest that p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation.

Original languageEnglish
Pages (from-to)209-221
Number of pages13
JournalCell
Volume120
Issue number2
DOIs
Publication statusPublished - 2005 Jan 28

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR'. Together they form a unique fingerprint.

  • Cite this

    Park, B. J., Kang, J. W., Lee, S. W., Choi, S. J., Shin, Y. K., Ahn, Y. H., Choi, Y. H., Choi, D., Lee, K. S., & Kim, S. (2005). The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Cell, 120(2), 209-221. https://doi.org/10.1016/j.cell.2004.11.054