The Hippo signaling pathway in stem cell biology and cancer

Jung Soon Mo, Hyun Woo Park, Kun Liang Guan

Research output: Contribution to journalReview articlepeer-review

294 Citations (Scopus)

Abstract

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer. The Hippo pathway regulates tissue homeostasis and organ size by controlling tissue-specific stem cells, and dysregulation of this pathway is associated with various diseases. This review focuses on the role of Hippo signaling in stem cell biology and its potential implications in tissue homeostasis and cancer.

Original languageEnglish
Pages (from-to)642-656
Number of pages15
JournalEMBO Reports
Volume15
Issue number6
DOIs
Publication statusPublished - 2014 Jun

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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