The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria

S. H. Kim, J. H. Choi, K. W. Lee, S. H. Kim, E. S. Shin, H. B. Oh, C. H. Suh, D. H. Nahm, Haem Sim Park

Research output: Contribution to journalArticle

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Abstract

Background: Urticaria/angioedema is a common aspirin-induced allergy: however, its pathogenic mechanism is not understood. Objective: In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirin-intolerant asthma and normal control in a Korean population. Methods: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis. Results: The allele frequencies of HLA-DRB1*1302 (18.1%) and HLA-DQB1*0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P = 0.0004; 2.0%, P = 0.0024) and in normal controls (8.1%, P = 0.0005; 3.2%. P = 0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P > 0.05, respectively). In haplotype analysis, the HLA-DRB1* 1302-DQB1*0609-DPB1*0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P = 0.0014) and normal controls (2.0%, P = 0.0006). Conclusion: These findings suggest that the HLA-DRB1*1302-DQB1*0609-DPB1*0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalClinical and Experimental Allergy
Volume35
Issue number3
DOIs
Publication statusPublished - 2005 Mar 1

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Urticaria
HLA Antigens
Genetic Markers
Haplotypes
Aspirin
Angioedema
Asthma
Non-Steroidal Anti-Inflammatory Agents
DNA Sequence Analysis
Gene Frequency
Immunoglobulin E
Hypersensitivity
Genotype
Phenotype

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Kim, S. H. ; Choi, J. H. ; Lee, K. W. ; Kim, S. H. ; Shin, E. S. ; Oh, H. B. ; Suh, C. H. ; Nahm, D. H. ; Park, Haem Sim. / The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. In: Clinical and Experimental Allergy. 2005 ; Vol. 35, No. 3. pp. 339-344.
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title = "The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria",
abstract = "Background: Urticaria/angioedema is a common aspirin-induced allergy: however, its pathogenic mechanism is not understood. Objective: In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirin-intolerant asthma and normal control in a Korean population. Methods: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis. Results: The allele frequencies of HLA-DRB1*1302 (18.1{\%}) and HLA-DQB1*0609 (10.1{\%}) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3{\%}, P = 0.0004; 2.0{\%}, P = 0.0024) and in normal controls (8.1{\%}, P = 0.0005; 3.2{\%}. P = 0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P > 0.05, respectively). In haplotype analysis, the HLA-DRB1* 1302-DQB1*0609-DPB1*0201 was significantly higher in the aspirin-induced urticaria (8.0{\%}) than in the aspirin-intolerant asthma (0.7{\%}, P = 0.0014) and normal controls (2.0{\%}, P = 0.0006). Conclusion: These findings suggest that the HLA-DRB1*1302-DQB1*0609-DPB1*0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.",
author = "Kim, {S. H.} and Choi, {J. H.} and Lee, {K. W.} and Kim, {S. H.} and Shin, {E. S.} and Oh, {H. B.} and Suh, {C. H.} and Nahm, {D. H.} and Park, {Haem Sim}",
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The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. / Kim, S. H.; Choi, J. H.; Lee, K. W.; Kim, S. H.; Shin, E. S.; Oh, H. B.; Suh, C. H.; Nahm, D. H.; Park, Haem Sim.

In: Clinical and Experimental Allergy, Vol. 35, No. 3, 01.03.2005, p. 339-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria

AU - Kim, S. H.

AU - Choi, J. H.

AU - Lee, K. W.

AU - Kim, S. H.

AU - Shin, E. S.

AU - Oh, H. B.

AU - Suh, C. H.

AU - Nahm, D. H.

AU - Park, Haem Sim

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Background: Urticaria/angioedema is a common aspirin-induced allergy: however, its pathogenic mechanism is not understood. Objective: In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirin-intolerant asthma and normal control in a Korean population. Methods: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis. Results: The allele frequencies of HLA-DRB1*1302 (18.1%) and HLA-DQB1*0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P = 0.0004; 2.0%, P = 0.0024) and in normal controls (8.1%, P = 0.0005; 3.2%. P = 0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P > 0.05, respectively). In haplotype analysis, the HLA-DRB1* 1302-DQB1*0609-DPB1*0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P = 0.0014) and normal controls (2.0%, P = 0.0006). Conclusion: These findings suggest that the HLA-DRB1*1302-DQB1*0609-DPB1*0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.

AB - Background: Urticaria/angioedema is a common aspirin-induced allergy: however, its pathogenic mechanism is not understood. Objective: In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirin-intolerant asthma and normal control in a Korean population. Methods: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis. Results: The allele frequencies of HLA-DRB1*1302 (18.1%) and HLA-DQB1*0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P = 0.0004; 2.0%, P = 0.0024) and in normal controls (8.1%, P = 0.0005; 3.2%. P = 0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P > 0.05, respectively). In haplotype analysis, the HLA-DRB1* 1302-DQB1*0609-DPB1*0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P = 0.0014) and normal controls (2.0%, P = 0.0006). Conclusion: These findings suggest that the HLA-DRB1*1302-DQB1*0609-DPB1*0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.

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