The human proteome project: Current state and future direction

Pierre Legrain, Ruedi Aebersold, Alexander Archakov, Amos Bairoch, Kumar Bala, Laura Beretta, John Bergeron, Christoph H. Borchers, Garry L. Corthals, Catherine E. Costello, Eric W. Deutsch, Bruno Domon, William Hancock, Fuchu He, Denis Hochstrasser, György Marko-Varga, Ghasem Hosseini Salekdeh, Salvatore Sechi, Michael Snyder, Sudhir SrivastavaMathias Uhlén, Cathy H. Wu, Tadashi Yamamoto, Young Ki Paik, Gilbert S. Omenn

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

Original languageEnglish
JournalMolecular and Cellular Proteomics
Volume10
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Proteome
Proteins
Genes
Human Genome Project
Direction compound
Precision Medicine
Biomolecules
Knowledge Bases
Bioinformatics
Chromosomes
Medicine
Computational Biology
Mass spectrometry
Research
Mass Spectrometry
Research Personnel
Planning
Antibodies

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology

Cite this

Legrain, P., Aebersold, R., Archakov, A., Bairoch, A., Bala, K., Beretta, L., ... Omenn, G. S. (2011). The human proteome project: Current state and future direction. Molecular and Cellular Proteomics, 10(7). https://doi.org/10.1074/mcp.M111.009993
Legrain, Pierre ; Aebersold, Ruedi ; Archakov, Alexander ; Bairoch, Amos ; Bala, Kumar ; Beretta, Laura ; Bergeron, John ; Borchers, Christoph H. ; Corthals, Garry L. ; Costello, Catherine E. ; Deutsch, Eric W. ; Domon, Bruno ; Hancock, William ; He, Fuchu ; Hochstrasser, Denis ; Marko-Varga, György ; Salekdeh, Ghasem Hosseini ; Sechi, Salvatore ; Snyder, Michael ; Srivastava, Sudhir ; Uhlén, Mathias ; Wu, Cathy H. ; Yamamoto, Tadashi ; Paik, Young Ki ; Omenn, Gilbert S. / The human proteome project : Current state and future direction. In: Molecular and Cellular Proteomics. 2011 ; Vol. 10, No. 7.
@article{d4e6c418338748c9a2a58b4f70bdbc1d,
title = "The human proteome project: Current state and future direction",
abstract = "After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30{\%} of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.",
author = "Pierre Legrain and Ruedi Aebersold and Alexander Archakov and Amos Bairoch and Kumar Bala and Laura Beretta and John Bergeron and Borchers, {Christoph H.} and Corthals, {Garry L.} and Costello, {Catherine E.} and Deutsch, {Eric W.} and Bruno Domon and William Hancock and Fuchu He and Denis Hochstrasser and Gy{\"o}rgy Marko-Varga and Salekdeh, {Ghasem Hosseini} and Salvatore Sechi and Michael Snyder and Sudhir Srivastava and Mathias Uhl{\'e}n and Wu, {Cathy H.} and Tadashi Yamamoto and Paik, {Young Ki} and Omenn, {Gilbert S.}",
year = "2011",
month = "7",
day = "1",
doi = "10.1074/mcp.M111.009993",
language = "English",
volume = "10",
journal = "Molecular and Cellular Proteomics",
issn = "1535-9476",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "7",

}

Legrain, P, Aebersold, R, Archakov, A, Bairoch, A, Bala, K, Beretta, L, Bergeron, J, Borchers, CH, Corthals, GL, Costello, CE, Deutsch, EW, Domon, B, Hancock, W, He, F, Hochstrasser, D, Marko-Varga, G, Salekdeh, GH, Sechi, S, Snyder, M, Srivastava, S, Uhlén, M, Wu, CH, Yamamoto, T, Paik, YK & Omenn, GS 2011, 'The human proteome project: Current state and future direction', Molecular and Cellular Proteomics, vol. 10, no. 7. https://doi.org/10.1074/mcp.M111.009993

The human proteome project : Current state and future direction. / Legrain, Pierre; Aebersold, Ruedi; Archakov, Alexander; Bairoch, Amos; Bala, Kumar; Beretta, Laura; Bergeron, John; Borchers, Christoph H.; Corthals, Garry L.; Costello, Catherine E.; Deutsch, Eric W.; Domon, Bruno; Hancock, William; He, Fuchu; Hochstrasser, Denis; Marko-Varga, György; Salekdeh, Ghasem Hosseini; Sechi, Salvatore; Snyder, Michael; Srivastava, Sudhir; Uhlén, Mathias; Wu, Cathy H.; Yamamoto, Tadashi; Paik, Young Ki; Omenn, Gilbert S.

In: Molecular and Cellular Proteomics, Vol. 10, No. 7, 01.07.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The human proteome project

T2 - Current state and future direction

AU - Legrain, Pierre

AU - Aebersold, Ruedi

AU - Archakov, Alexander

AU - Bairoch, Amos

AU - Bala, Kumar

AU - Beretta, Laura

AU - Bergeron, John

AU - Borchers, Christoph H.

AU - Corthals, Garry L.

AU - Costello, Catherine E.

AU - Deutsch, Eric W.

AU - Domon, Bruno

AU - Hancock, William

AU - He, Fuchu

AU - Hochstrasser, Denis

AU - Marko-Varga, György

AU - Salekdeh, Ghasem Hosseini

AU - Sechi, Salvatore

AU - Snyder, Michael

AU - Srivastava, Sudhir

AU - Uhlén, Mathias

AU - Wu, Cathy H.

AU - Yamamoto, Tadashi

AU - Paik, Young Ki

AU - Omenn, Gilbert S.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

AB - After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

UR - http://www.scopus.com/inward/record.url?scp=79960179572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960179572&partnerID=8YFLogxK

U2 - 10.1074/mcp.M111.009993

DO - 10.1074/mcp.M111.009993

M3 - Article

C2 - 21742803

AN - SCOPUS:79960179572

VL - 10

JO - Molecular and Cellular Proteomics

JF - Molecular and Cellular Proteomics

SN - 1535-9476

IS - 7

ER -

Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L et al. The human proteome project: Current state and future direction. Molecular and Cellular Proteomics. 2011 Jul 1;10(7). https://doi.org/10.1074/mcp.M111.009993