The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

Jae Hee Cho, Ja Sung Choi, Song Wook Chun, Sangheun Lee, Ki Jun Han, Heeman Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalGut and Liver
Volume10
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

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Genetic Polymorphisms
Peptic Ulcer
Interleukin-1
Ethnic Groups
Aspirin
Single Nucleotide Polymorphism
Genotype
Odds Ratio
Confidence Intervals
DNA Sequence Analysis
Introns
Population
Genes
Exons
Multivariate Analysis
DNA
Research

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Cho, Jae Hee ; Choi, Ja Sung ; Chun, Song Wook ; Lee, Sangheun ; Han, Ki Jun ; Kim, Heeman. / The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group. In: Gut and Liver. 2016 ; Vol. 10, No. 3. pp. 362-368.
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abstract = "Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95{\%} confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95{\%} CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.",
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The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group. / Cho, Jae Hee; Choi, Ja Sung; Chun, Song Wook; Lee, Sangheun; Han, Ki Jun; Kim, Heeman.

In: Gut and Liver, Vol. 10, No. 3, 01.01.2016, p. 362-368.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

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AU - Choi, Ja Sung

AU - Chun, Song Wook

AU - Lee, Sangheun

AU - Han, Ki Jun

AU - Kim, Heeman

PY - 2016/1/1

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N2 - Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

AB - Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

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