The impact of blood flow rate during hemodialysis on all-cause mortality

Kyung Yoon Chang, Su Hyun Kim, Young Ok Kim, Dong Chan Jin, Ho Chul Song, Euy Jin Choi, Yong Lim Kim, Yon Su Kim, Shin-Wook Kang, Nam Ho Kim, Chul Woo Yang, Yong Kyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients. Methods: Prevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality. Results: A total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24%) and in the BFR ≥ 250 mL/min was 858 (76%). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95% confidence interval, 1.00 to 2.73; p = 0.048). Conclusions: Our data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.

Original languageEnglish
Pages (from-to)1131-1139
Number of pages9
JournalKorean Journal of Internal Medicine
Volume31
Issue number6
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Renal Dialysis
Mortality
Dialysis
Kaplan-Meier Estimate
Korea
Blood Group Antigens
Chronic Kidney Failure
Registries
Regression Analysis
Confidence Intervals
Morbidity
Research

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Chang, K. Y., Kim, S. H., Kim, Y. O., Jin, D. C., Song, H. C., Choi, E. J., ... Kim, Y. K. (2016). The impact of blood flow rate during hemodialysis on all-cause mortality. Korean Journal of Internal Medicine, 31(6), 1131-1139. https://doi.org/10.3904/kjim.2015.111
Chang, Kyung Yoon ; Kim, Su Hyun ; Kim, Young Ok ; Jin, Dong Chan ; Song, Ho Chul ; Choi, Euy Jin ; Kim, Yong Lim ; Kim, Yon Su ; Kang, Shin-Wook ; Kim, Nam Ho ; Yang, Chul Woo ; Kim, Yong Kyun. / The impact of blood flow rate during hemodialysis on all-cause mortality. In: Korean Journal of Internal Medicine. 2016 ; Vol. 31, No. 6. pp. 1131-1139.
@article{4fbd438b12e44c45a3886df80d97c76e,
title = "The impact of blood flow rate during hemodialysis on all-cause mortality",
abstract = "Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients. Methods: Prevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality. Results: A total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24{\%}) and in the BFR ≥ 250 mL/min was 858 (76{\%}). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95{\%} confidence interval, 1.00 to 2.73; p = 0.048). Conclusions: Our data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.",
author = "Chang, {Kyung Yoon} and Kim, {Su Hyun} and Kim, {Young Ok} and Jin, {Dong Chan} and Song, {Ho Chul} and Choi, {Euy Jin} and Kim, {Yong Lim} and Kim, {Yon Su} and Shin-Wook Kang and Kim, {Nam Ho} and Yang, {Chul Woo} and Kim, {Yong Kyun}",
year = "2016",
month = "11",
day = "1",
doi = "10.3904/kjim.2015.111",
language = "English",
volume = "31",
pages = "1131--1139",
journal = "Korean Journal of Internal Medicine",
issn = "1226-3303",
publisher = "Korean Association of Internal Medicine",
number = "6",

}

Chang, KY, Kim, SH, Kim, YO, Jin, DC, Song, HC, Choi, EJ, Kim, YL, Kim, YS, Kang, S-W, Kim, NH, Yang, CW & Kim, YK 2016, 'The impact of blood flow rate during hemodialysis on all-cause mortality', Korean Journal of Internal Medicine, vol. 31, no. 6, pp. 1131-1139. https://doi.org/10.3904/kjim.2015.111

The impact of blood flow rate during hemodialysis on all-cause mortality. / Chang, Kyung Yoon; Kim, Su Hyun; Kim, Young Ok; Jin, Dong Chan; Song, Ho Chul; Choi, Euy Jin; Kim, Yong Lim; Kim, Yon Su; Kang, Shin-Wook; Kim, Nam Ho; Yang, Chul Woo; Kim, Yong Kyun.

In: Korean Journal of Internal Medicine, Vol. 31, No. 6, 01.11.2016, p. 1131-1139.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The impact of blood flow rate during hemodialysis on all-cause mortality

AU - Chang, Kyung Yoon

AU - Kim, Su Hyun

AU - Kim, Young Ok

AU - Jin, Dong Chan

AU - Song, Ho Chul

AU - Choi, Euy Jin

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Kang, Shin-Wook

AU - Kim, Nam Ho

AU - Yang, Chul Woo

AU - Kim, Yong Kyun

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients. Methods: Prevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality. Results: A total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24%) and in the BFR ≥ 250 mL/min was 858 (76%). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95% confidence interval, 1.00 to 2.73; p = 0.048). Conclusions: Our data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.

AB - Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients. Methods: Prevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality. Results: A total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24%) and in the BFR ≥ 250 mL/min was 858 (76%). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95% confidence interval, 1.00 to 2.73; p = 0.048). Conclusions: Our data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.

UR - http://www.scopus.com/inward/record.url?scp=84994391715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994391715&partnerID=8YFLogxK

U2 - 10.3904/kjim.2015.111

DO - 10.3904/kjim.2015.111

M3 - Article

C2 - 26898596

AN - SCOPUS:84994391715

VL - 31

SP - 1131

EP - 1139

JO - Korean Journal of Internal Medicine

JF - Korean Journal of Internal Medicine

SN - 1226-3303

IS - 6

ER -