The impact of blood flow rate during hemodialysis on all-cause mortality

Kyung Yoon Chang, Su Hyun Kim, Young Ok Kim, Dong Chan Jin, Ho Chul Song, Euy Jin Choi, Yong Lim Kim, Yon Su Kim, Shin Wook Kang, Nam Ho Kim, Chul Woo Yang, Yong Kyun Kim

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Abstract

Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients. Methods: Prevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality. Results: A total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24%) and in the BFR ≥ 250 mL/min was 858 (76%). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95% confidence interval, 1.00 to 2.73; p = 0.048). Conclusions: Our data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.

Original languageEnglish
Pages (from-to)1131-1139
Number of pages9
JournalKorean Journal of Internal Medicine
Volume31
Issue number6
DOIs
Publication statusPublished - 2016 Nov

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Chang, K. Y., Kim, S. H., Kim, Y. O., Jin, D. C., Song, H. C., Choi, E. J., Kim, Y. L., Kim, Y. S., Kang, S. W., Kim, N. H., Yang, C. W., & Kim, Y. K. (2016). The impact of blood flow rate during hemodialysis on all-cause mortality. Korean Journal of Internal Medicine, 31(6), 1131-1139. https://doi.org/10.3904/kjim.2015.111