The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region

on behalf of the Asia Pacific Cohort Studies Collaboration

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD).Methods: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compared across the BMI groups, testing for interactions.Results: In the analyses for TC, HDLC and TG, there were 3121, 714 and 808 CHD events during a mean follow-up of 6.7 years The risk of CHD increased monotonically with increasing TC and decreasing HDLC in all BMI subgroups without evidence of heterogeneity (p for interaction > 0.4). In contrast, the hazard ratio for CHD for a one SD increase in log-transformed TG increased from 1.07 (95%CI 0.72-1.59) in underweight, 1.26 (1.10-1.44) in normal weight, 1.27 (1.08-1.49) in high-normal weight, 1.37 (1.22-1.55) in overweight, to 1.61(1.30-1.99) in obesity (p = 0.01 for interaction trend). These associations were attenuated (p = 0.07 for interaction) but remained significant in the overweight and obese after further adjustment for TC and HDLC.Conclusions: Greater excess body weight exacerbated the effects of TG, but not TC or HDLC, on CHD, suggesting that additional effort is required to reduce TG in the overweight and obese.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalPreventive Medicine Reports
Volume3
DOIs
Publication statusPublished - 2016 Jun 1

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Coronary Disease
Body Mass Index
HDL Cholesterol
Lipids
Cholesterol
Triglycerides
Thinness
Weights and Measures
Proportional Hazards Models
Cohort Studies
Obesity
Smoking
Body Weight
lipoprotein triglyceride

All Science Journal Classification (ASJC) codes

  • Health Informatics
  • Public Health, Environmental and Occupational Health

Cite this

@article{a53a8b72c095416da05f4b969ab82408,
title = "The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region",
abstract = "Objective: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD).Methods: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compared across the BMI groups, testing for interactions.Results: In the analyses for TC, HDLC and TG, there were 3121, 714 and 808 CHD events during a mean follow-up of 6.7 years The risk of CHD increased monotonically with increasing TC and decreasing HDLC in all BMI subgroups without evidence of heterogeneity (p for interaction > 0.4). In contrast, the hazard ratio for CHD for a one SD increase in log-transformed TG increased from 1.07 (95{\%}CI 0.72-1.59) in underweight, 1.26 (1.10-1.44) in normal weight, 1.27 (1.08-1.49) in high-normal weight, 1.37 (1.22-1.55) in overweight, to 1.61(1.30-1.99) in obesity (p = 0.01 for interaction trend). These associations were attenuated (p = 0.07 for interaction) but remained significant in the overweight and obese after further adjustment for TC and HDLC.Conclusions: Greater excess body weight exacerbated the effects of TG, but not TC or HDLC, on CHD, suggesting that additional effort is required to reduce TG in the overweight and obese.",
author = "{on behalf of the Asia Pacific Cohort Studies Collaboration} and Yoichiro Hirakawa and Lam, {Tai Hing} and Timothy Welborn and Kim, {Hyeon Chang} and Suzanne Ho and Xianghua Fang and Hirotsugu Ueshima and Il Suh and Graham Giles and Mark Woodward",
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The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region. / on behalf of the Asia Pacific Cohort Studies Collaboration.

In: Preventive Medicine Reports, Vol. 3, 01.06.2016, p. 79-82.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region

AU - on behalf of the Asia Pacific Cohort Studies Collaboration

AU - Hirakawa, Yoichiro

AU - Lam, Tai Hing

AU - Welborn, Timothy

AU - Kim, Hyeon Chang

AU - Ho, Suzanne

AU - Fang, Xianghua

AU - Ueshima, Hirotsugu

AU - Suh, Il

AU - Giles, Graham

AU - Woodward, Mark

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD).Methods: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compared across the BMI groups, testing for interactions.Results: In the analyses for TC, HDLC and TG, there were 3121, 714 and 808 CHD events during a mean follow-up of 6.7 years The risk of CHD increased monotonically with increasing TC and decreasing HDLC in all BMI subgroups without evidence of heterogeneity (p for interaction > 0.4). In contrast, the hazard ratio for CHD for a one SD increase in log-transformed TG increased from 1.07 (95%CI 0.72-1.59) in underweight, 1.26 (1.10-1.44) in normal weight, 1.27 (1.08-1.49) in high-normal weight, 1.37 (1.22-1.55) in overweight, to 1.61(1.30-1.99) in obesity (p = 0.01 for interaction trend). These associations were attenuated (p = 0.07 for interaction) but remained significant in the overweight and obese after further adjustment for TC and HDLC.Conclusions: Greater excess body weight exacerbated the effects of TG, but not TC or HDLC, on CHD, suggesting that additional effort is required to reduce TG in the overweight and obese.

AB - Objective: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD).Methods: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compared across the BMI groups, testing for interactions.Results: In the analyses for TC, HDLC and TG, there were 3121, 714 and 808 CHD events during a mean follow-up of 6.7 years The risk of CHD increased monotonically with increasing TC and decreasing HDLC in all BMI subgroups without evidence of heterogeneity (p for interaction > 0.4). In contrast, the hazard ratio for CHD for a one SD increase in log-transformed TG increased from 1.07 (95%CI 0.72-1.59) in underweight, 1.26 (1.10-1.44) in normal weight, 1.27 (1.08-1.49) in high-normal weight, 1.37 (1.22-1.55) in overweight, to 1.61(1.30-1.99) in obesity (p = 0.01 for interaction trend). These associations were attenuated (p = 0.07 for interaction) but remained significant in the overweight and obese after further adjustment for TC and HDLC.Conclusions: Greater excess body weight exacerbated the effects of TG, but not TC or HDLC, on CHD, suggesting that additional effort is required to reduce TG in the overweight and obese.

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