The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

Steffen E. Petersen, Mihir M. Sanghvi, Nay Aung, Jackie A. Cooper, José Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M. Lee, Valentina Carapella, Young Jin Kim, Stefan K. Piechnik, Stefan Neubauer

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Abstract

Aims: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. Methods: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors. Multivariable regression models were built to ascertain the association of risk factors on left ventricular (LV), right ventricular (RV), left atrial (LA) and right atrial (RA) CMR parameters. Results: 4,651 participants were included in the analysis. All modifiable risk factors had significant effects on differing atrial and ventricular parameters. BMI was the modifiable risk factor most consistently associated with subclinical changes to CMR parameters, particularly in relation to higher LV mass (+8.3% per SD [4.3 kg/m2], 95% CI: 7.6 to 8.9%), LV (EDV: +4.8% per SD, 95% CI: 4.2 to 5.4%); ESV: +4.4% per SD, 95% CI: 3.5 to 5.3%), RV (EDV: +5.3% per SD, 95% CI: 4.7 to 5.9%; ESV: +5.4% per SD, 95% CI: 4.5 to 6.4%) and LA maximal (+8.6% per SD, 95% CI: 7.4 to 9.7%) volumes. Increases in SBP were associated with higher LV mass (+6.8% per SD, 95% CI: 5.9 to 7.7%), LV (EDV: +4.5% per SD, 95% CI: 3.6 to 5.4%; ESV: +2.0% per SD, 95% CI: 0.8 to 3.3%) volumes. The presence of diabetes or high cholesterol resulted in smaller volumes and lower ejection fractions. Conclusions: Modifiable risk factors are associated with subclinical alterations in structure and function in all four cardiac chambers. BMI and systolic blood pressure are the most important modifiable risk factors affecting CMR parameters known to be linked to adverse outcomes.

Original languageEnglish
Article numbere0185114
JournalPloS one
Volume12
Issue number10
DOIs
Publication statusPublished - 2017 Oct

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risk factors
image analysis
Imaging techniques
Magnetic resonance
Blood Pressure
Blood pressure
Magnetic Resonance Spectroscopy
body mass index
Body Mass Index
systolic blood pressure
Medical problems
diabetes
Cholesterol
cholesterol
Ventricular Function
diastolic blood pressure
nationalities and ethnic groups
cardiovascular diseases
exercise
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Petersen, S. E., Sanghvi, M. M., Aung, N., Cooper, J. A., Paiva, J. M., Zemrak, F., ... Neubauer, S. (2017). The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study. PloS one, 12(10), [e0185114]. https://doi.org/10.1371/journal.pone.0185114
Petersen, Steffen E. ; Sanghvi, Mihir M. ; Aung, Nay ; Cooper, Jackie A. ; Paiva, José Miguel ; Zemrak, Filip ; Fung, Kenneth ; Lukaschuk, Elena ; Lee, Aaron M. ; Carapella, Valentina ; Kim, Young Jin ; Piechnik, Stefan K. ; Neubauer, Stefan. / The impact of cardiovascular risk factors on cardiac structure and function : Insights from the UK Biobank imaging enhancement study. In: PloS one. 2017 ; Vol. 12, No. 10.
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abstract = "Aims: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. Methods: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors. Multivariable regression models were built to ascertain the association of risk factors on left ventricular (LV), right ventricular (RV), left atrial (LA) and right atrial (RA) CMR parameters. Results: 4,651 participants were included in the analysis. All modifiable risk factors had significant effects on differing atrial and ventricular parameters. BMI was the modifiable risk factor most consistently associated with subclinical changes to CMR parameters, particularly in relation to higher LV mass (+8.3{\%} per SD [4.3 kg/m2], 95{\%} CI: 7.6 to 8.9{\%}), LV (EDV: +4.8{\%} per SD, 95{\%} CI: 4.2 to 5.4{\%}); ESV: +4.4{\%} per SD, 95{\%} CI: 3.5 to 5.3{\%}), RV (EDV: +5.3{\%} per SD, 95{\%} CI: 4.7 to 5.9{\%}; ESV: +5.4{\%} per SD, 95{\%} CI: 4.5 to 6.4{\%}) and LA maximal (+8.6{\%} per SD, 95{\%} CI: 7.4 to 9.7{\%}) volumes. Increases in SBP were associated with higher LV mass (+6.8{\%} per SD, 95{\%} CI: 5.9 to 7.7{\%}), LV (EDV: +4.5{\%} per SD, 95{\%} CI: 3.6 to 5.4{\%}; ESV: +2.0{\%} per SD, 95{\%} CI: 0.8 to 3.3{\%}) volumes. The presence of diabetes or high cholesterol resulted in smaller volumes and lower ejection fractions. Conclusions: Modifiable risk factors are associated with subclinical alterations in structure and function in all four cardiac chambers. BMI and systolic blood pressure are the most important modifiable risk factors affecting CMR parameters known to be linked to adverse outcomes.",
author = "Petersen, {Steffen E.} and Sanghvi, {Mihir M.} and Nay Aung and Cooper, {Jackie A.} and Paiva, {Jos{\'e} Miguel} and Filip Zemrak and Kenneth Fung and Elena Lukaschuk and Lee, {Aaron M.} and Valentina Carapella and Kim, {Young Jin} and Piechnik, {Stefan K.} and Stefan Neubauer",
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Petersen, SE, Sanghvi, MM, Aung, N, Cooper, JA, Paiva, JM, Zemrak, F, Fung, K, Lukaschuk, E, Lee, AM, Carapella, V, Kim, YJ, Piechnik, SK & Neubauer, S 2017, 'The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study', PloS one, vol. 12, no. 10, e0185114. https://doi.org/10.1371/journal.pone.0185114

The impact of cardiovascular risk factors on cardiac structure and function : Insights from the UK Biobank imaging enhancement study. / Petersen, Steffen E.; Sanghvi, Mihir M.; Aung, Nay; Cooper, Jackie A.; Paiva, José Miguel; Zemrak, Filip; Fung, Kenneth; Lukaschuk, Elena; Lee, Aaron M.; Carapella, Valentina; Kim, Young Jin; Piechnik, Stefan K.; Neubauer, Stefan.

In: PloS one, Vol. 12, No. 10, e0185114, 10.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The impact of cardiovascular risk factors on cardiac structure and function

T2 - Insights from the UK Biobank imaging enhancement study

AU - Petersen, Steffen E.

AU - Sanghvi, Mihir M.

AU - Aung, Nay

AU - Cooper, Jackie A.

AU - Paiva, José Miguel

AU - Zemrak, Filip

AU - Fung, Kenneth

AU - Lukaschuk, Elena

AU - Lee, Aaron M.

AU - Carapella, Valentina

AU - Kim, Young Jin

AU - Piechnik, Stefan K.

AU - Neubauer, Stefan

PY - 2017/10

Y1 - 2017/10

N2 - Aims: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. Methods: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors. Multivariable regression models were built to ascertain the association of risk factors on left ventricular (LV), right ventricular (RV), left atrial (LA) and right atrial (RA) CMR parameters. Results: 4,651 participants were included in the analysis. All modifiable risk factors had significant effects on differing atrial and ventricular parameters. BMI was the modifiable risk factor most consistently associated with subclinical changes to CMR parameters, particularly in relation to higher LV mass (+8.3% per SD [4.3 kg/m2], 95% CI: 7.6 to 8.9%), LV (EDV: +4.8% per SD, 95% CI: 4.2 to 5.4%); ESV: +4.4% per SD, 95% CI: 3.5 to 5.3%), RV (EDV: +5.3% per SD, 95% CI: 4.7 to 5.9%; ESV: +5.4% per SD, 95% CI: 4.5 to 6.4%) and LA maximal (+8.6% per SD, 95% CI: 7.4 to 9.7%) volumes. Increases in SBP were associated with higher LV mass (+6.8% per SD, 95% CI: 5.9 to 7.7%), LV (EDV: +4.5% per SD, 95% CI: 3.6 to 5.4%; ESV: +2.0% per SD, 95% CI: 0.8 to 3.3%) volumes. The presence of diabetes or high cholesterol resulted in smaller volumes and lower ejection fractions. Conclusions: Modifiable risk factors are associated with subclinical alterations in structure and function in all four cardiac chambers. BMI and systolic blood pressure are the most important modifiable risk factors affecting CMR parameters known to be linked to adverse outcomes.

AB - Aims: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. Methods: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors. Multivariable regression models were built to ascertain the association of risk factors on left ventricular (LV), right ventricular (RV), left atrial (LA) and right atrial (RA) CMR parameters. Results: 4,651 participants were included in the analysis. All modifiable risk factors had significant effects on differing atrial and ventricular parameters. BMI was the modifiable risk factor most consistently associated with subclinical changes to CMR parameters, particularly in relation to higher LV mass (+8.3% per SD [4.3 kg/m2], 95% CI: 7.6 to 8.9%), LV (EDV: +4.8% per SD, 95% CI: 4.2 to 5.4%); ESV: +4.4% per SD, 95% CI: 3.5 to 5.3%), RV (EDV: +5.3% per SD, 95% CI: 4.7 to 5.9%; ESV: +5.4% per SD, 95% CI: 4.5 to 6.4%) and LA maximal (+8.6% per SD, 95% CI: 7.4 to 9.7%) volumes. Increases in SBP were associated with higher LV mass (+6.8% per SD, 95% CI: 5.9 to 7.7%), LV (EDV: +4.5% per SD, 95% CI: 3.6 to 5.4%; ESV: +2.0% per SD, 95% CI: 0.8 to 3.3%) volumes. The presence of diabetes or high cholesterol resulted in smaller volumes and lower ejection fractions. Conclusions: Modifiable risk factors are associated with subclinical alterations in structure and function in all four cardiac chambers. BMI and systolic blood pressure are the most important modifiable risk factors affecting CMR parameters known to be linked to adverse outcomes.

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