The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

Ja Seung Koo, Seho Park, Seung Il Kim, Sarah Lee, Byeong Woo Park

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We aimed to investigate the expression of caveolin- 1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.

Original languageEnglish
Pages (from-to)787-799
Number of pages13
JournalTumor Biology
Volume32
Issue number4
DOIs
Publication statusPublished - 2011 Aug

All Science Journal Classification (ASJC) codes

  • Cancer Research

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