The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients

Sung Jin Moon, Dong Ki Kim, Jae Hyun Chang, Chan Ho Kim, Hyun Wook Kim, Sun Young Park, SeungHyeok Han, Jung Eun Lee, TaeHyun Yoo, Dae Suk Han, Shin-Wook Kang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of different dialysis modalities on skin colour in HD patients.Methods. Eighty-two ESRD patients on HD were divided into low-flux HD (LF-HD), HF-HD and HDF groups. The melanin index (MI) and erythema index (EI) of the abdomen and the flexor side of the forearm (non-sun-exposed areas) and the forehead (sun-exposed area) were determined by using a narrow-band reflectance spectrophotometer at baseline and after 12 months.Results. Even though absolute values of baseline and follow-up MI and EI of the three sites were comparable among the three groups, forehead MI and EI were significantly decreased after 12 months in the HDF group (P < 0.05). In addition, the change in forehead MI was significantly greater in the HDF than in the LF-HD group (-1.0 ± 2.4 versus 0.3 ± 1.6, P < 0.05). Moreover, β2-microglobulin reduction rates were negatively correlated with both changes in forehead MI (P < 0.01) and EI (P < 0.05).Conclusions. Skin colour of sun-exposed areas was signi- ficantly decreased in ESRD patients receiving HDF therapy, suggesting that enhanced removal of MMW substances by convection may prevent or reduce hyperpigmentation in HD patients.

Original languageEnglish
Pages (from-to)2803-2809
Number of pages7
JournalNephrology Dialysis Transplantation
Volume24
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

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Hemodiafiltration
Hyperpigmentation
Melanins
Forehead
Renal Dialysis
Dialysis
Erythema
Skin
Chronic Kidney Failure
Skin Pigmentation
Molecular Weight
Solar System
Convection
Forearm
Abdomen

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Moon, Sung Jin ; Kim, Dong Ki ; Chang, Jae Hyun ; Kim, Chan Ho ; Kim, Hyun Wook ; Park, Sun Young ; Han, SeungHyeok ; Lee, Jung Eun ; Yoo, TaeHyun ; Han, Dae Suk ; Kang, Shin-Wook. / The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients. In: Nephrology Dialysis Transplantation. 2009 ; Vol. 24, No. 9. pp. 2803-2809.
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abstract = "Background. Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of different dialysis modalities on skin colour in HD patients.Methods. Eighty-two ESRD patients on HD were divided into low-flux HD (LF-HD), HF-HD and HDF groups. The melanin index (MI) and erythema index (EI) of the abdomen and the flexor side of the forearm (non-sun-exposed areas) and the forehead (sun-exposed area) were determined by using a narrow-band reflectance spectrophotometer at baseline and after 12 months.Results. Even though absolute values of baseline and follow-up MI and EI of the three sites were comparable among the three groups, forehead MI and EI were significantly decreased after 12 months in the HDF group (P < 0.05). In addition, the change in forehead MI was significantly greater in the HDF than in the LF-HD group (-1.0 ± 2.4 versus 0.3 ± 1.6, P < 0.05). Moreover, β2-microglobulin reduction rates were negatively correlated with both changes in forehead MI (P < 0.01) and EI (P < 0.05).Conclusions. Skin colour of sun-exposed areas was signi- ficantly decreased in ESRD patients receiving HDF therapy, suggesting that enhanced removal of MMW substances by convection may prevent or reduce hyperpigmentation in HD patients.",
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The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients. / Moon, Sung Jin; Kim, Dong Ki; Chang, Jae Hyun; Kim, Chan Ho; Kim, Hyun Wook; Park, Sun Young; Han, SeungHyeok; Lee, Jung Eun; Yoo, TaeHyun; Han, Dae Suk; Kang, Shin-Wook.

In: Nephrology Dialysis Transplantation, Vol. 24, No. 9, 01.09.2009, p. 2803-2809.

Research output: Contribution to journalArticle

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T1 - The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients

AU - Moon, Sung Jin

AU - Kim, Dong Ki

AU - Chang, Jae Hyun

AU - Kim, Chan Ho

AU - Kim, Hyun Wook

AU - Park, Sun Young

AU - Han, SeungHyeok

AU - Lee, Jung Eun

AU - Yoo, TaeHyun

AU - Han, Dae Suk

AU - Kang, Shin-Wook

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Background. Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of different dialysis modalities on skin colour in HD patients.Methods. Eighty-two ESRD patients on HD were divided into low-flux HD (LF-HD), HF-HD and HDF groups. The melanin index (MI) and erythema index (EI) of the abdomen and the flexor side of the forearm (non-sun-exposed areas) and the forehead (sun-exposed area) were determined by using a narrow-band reflectance spectrophotometer at baseline and after 12 months.Results. Even though absolute values of baseline and follow-up MI and EI of the three sites were comparable among the three groups, forehead MI and EI were significantly decreased after 12 months in the HDF group (P < 0.05). In addition, the change in forehead MI was significantly greater in the HDF than in the LF-HD group (-1.0 ± 2.4 versus 0.3 ± 1.6, P < 0.05). Moreover, β2-microglobulin reduction rates were negatively correlated with both changes in forehead MI (P < 0.01) and EI (P < 0.05).Conclusions. Skin colour of sun-exposed areas was signi- ficantly decreased in ESRD patients receiving HDF therapy, suggesting that enhanced removal of MMW substances by convection may prevent or reduce hyperpigmentation in HD patients.

AB - Background. Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of different dialysis modalities on skin colour in HD patients.Methods. Eighty-two ESRD patients on HD were divided into low-flux HD (LF-HD), HF-HD and HDF groups. The melanin index (MI) and erythema index (EI) of the abdomen and the flexor side of the forearm (non-sun-exposed areas) and the forehead (sun-exposed area) were determined by using a narrow-band reflectance spectrophotometer at baseline and after 12 months.Results. Even though absolute values of baseline and follow-up MI and EI of the three sites were comparable among the three groups, forehead MI and EI were significantly decreased after 12 months in the HDF group (P < 0.05). In addition, the change in forehead MI was significantly greater in the HDF than in the LF-HD group (-1.0 ± 2.4 versus 0.3 ± 1.6, P < 0.05). Moreover, β2-microglobulin reduction rates were negatively correlated with both changes in forehead MI (P < 0.01) and EI (P < 0.05).Conclusions. Skin colour of sun-exposed areas was signi- ficantly decreased in ESRD patients receiving HDF therapy, suggesting that enhanced removal of MMW substances by convection may prevent or reduce hyperpigmentation in HD patients.

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