The impact of nerve involvement on the prognosis of gastric cancer patients with curative gastrectomy: An international multicenter analysis

Kun Yang, Yu Qing Dan, Yoon Young Choi, Zong Guang Zhou, Woo Jin Hyung, Jian Kun Hu, Sung Hoon Noh

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the prognostic significance of PNI in gastric cancer. Study Design. The data of 2969 patients with gastric cancer and who had undergone curative gastrectomy from 2006 to 2010 in two high-volume hospitals of China and Korea were retrospectively analyzed. PNI positivity was identified when carcinoma cells were found to infiltrate into the perineurium or neural fascicles. The relationships between PNI and other clinicopathological factors were evaluated, and survival analyses were performed. Results. The presence of PNI was detected in 1055 of the 2969 patients (35.5%). Nationality, age, tumor location, size of tumor, differentiation of the tumor, pT stage, pN stage, lymphatic invasion, and vascular invasion had been associated with PNI positivity. The mean survival time of patients with and without PNI was 62.5 months and 87.3 months, respectively (P < 0:001). However, the presence of PNI was not an independent prognostic factor for gastric cancer, except for patients in stage III (P = 0:037, hazard ratio: 1.21, 95% confidence interval: 1.01-1.44). Conclusion. PNI occurs frequently in patients with gastric cancer, and the incidence of PNI increases with the staging of the tumor. The presence of PNI can provide additional information in predicting the survival outcome for those with stage III tumors.

Original languageEnglish
Article number8870562
JournalDisease markers
Volume2021
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Kun Yang et al.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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