The impact of obesity on subclinical coronary atherosclerosis according to the risk of cardiovascular disease

Seung Yul Lee, Hyuk-Jae Chang, Jimin Sung, Kwang Joon Kim, Sanghoon Shin, In Jeong Cho, ChiYoung Shim, Geu Ru Hong, Namsik Chung

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective To evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD). Methods A total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check-up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT-derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation. Results In the low-risk group for CVD, obesity measurements (standardized odds ratio, 95% confidence interval) of BMI (1.406, 1.197-1.652), WC (1.707, 1.434-2.032), visceral fat area (1.700, 1.438-2.009), and visceral-to-subcutaneous fat ratio (1.620, 1.379-1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate-to-high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low-risk group, WC (1.717, 1.172-2.514) and visceral-to-subcutaneous fat ratio (1.400, 1.029-1.904) were independent determinants of coronary calcification. Conclusions Obesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low-risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.

Original languageEnglish
Pages (from-to)1762-1768
Number of pages7
JournalObesity
Volume22
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

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Coronary Artery Disease
Cardiovascular Diseases
Obesity
Subcutaneous Fat
Waist Circumference
Intra-Abdominal Fat
Multidetector Computed Tomography
Body Mass Index
Abdominal Fat
Adipose Tissue
Odds Ratio
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Lee, Seung Yul ; Chang, Hyuk-Jae ; Sung, Jimin ; Kim, Kwang Joon ; Shin, Sanghoon ; Cho, In Jeong ; Shim, ChiYoung ; Hong, Geu Ru ; Chung, Namsik. / The impact of obesity on subclinical coronary atherosclerosis according to the risk of cardiovascular disease. In: Obesity. 2014 ; Vol. 22, No. 7. pp. 1762-1768.
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abstract = "Objective To evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD). Methods A total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check-up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT-derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation. Results In the low-risk group for CVD, obesity measurements (standardized odds ratio, 95{\%} confidence interval) of BMI (1.406, 1.197-1.652), WC (1.707, 1.434-2.032), visceral fat area (1.700, 1.438-2.009), and visceral-to-subcutaneous fat ratio (1.620, 1.379-1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate-to-high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low-risk group, WC (1.717, 1.172-2.514) and visceral-to-subcutaneous fat ratio (1.400, 1.029-1.904) were independent determinants of coronary calcification. Conclusions Obesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low-risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.",
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The impact of obesity on subclinical coronary atherosclerosis according to the risk of cardiovascular disease. / Lee, Seung Yul; Chang, Hyuk-Jae; Sung, Jimin; Kim, Kwang Joon; Shin, Sanghoon; Cho, In Jeong; Shim, ChiYoung; Hong, Geu Ru; Chung, Namsik.

In: Obesity, Vol. 22, No. 7, 01.01.2014, p. 1762-1768.

Research output: Contribution to journalArticle

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AU - Lee, Seung Yul

AU - Chang, Hyuk-Jae

AU - Sung, Jimin

AU - Kim, Kwang Joon

AU - Shin, Sanghoon

AU - Cho, In Jeong

AU - Shim, ChiYoung

AU - Hong, Geu Ru

AU - Chung, Namsik

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N2 - Objective To evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD). Methods A total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check-up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT-derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation. Results In the low-risk group for CVD, obesity measurements (standardized odds ratio, 95% confidence interval) of BMI (1.406, 1.197-1.652), WC (1.707, 1.434-2.032), visceral fat area (1.700, 1.438-2.009), and visceral-to-subcutaneous fat ratio (1.620, 1.379-1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate-to-high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low-risk group, WC (1.717, 1.172-2.514) and visceral-to-subcutaneous fat ratio (1.400, 1.029-1.904) were independent determinants of coronary calcification. Conclusions Obesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low-risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.

AB - Objective To evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD). Methods A total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check-up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT-derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation. Results In the low-risk group for CVD, obesity measurements (standardized odds ratio, 95% confidence interval) of BMI (1.406, 1.197-1.652), WC (1.707, 1.434-2.032), visceral fat area (1.700, 1.438-2.009), and visceral-to-subcutaneous fat ratio (1.620, 1.379-1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate-to-high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low-risk group, WC (1.717, 1.172-2.514) and visceral-to-subcutaneous fat ratio (1.400, 1.029-1.904) were independent determinants of coronary calcification. Conclusions Obesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low-risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.

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