The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B

Seungup Kim, doyoung kim, SangHoon Ahn, Heeman Kim, Jung Min Lee, Chae Yoon Chon, Young Nyun Park, KwangHyub Han, Junyong Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan® accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). Methodology: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. Results: The mean age of the patients was 44.4 years and the mean body mass index was 23.3±2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), Sl in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r=0.023, p=0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r=0.268, p<0.001), while steatosis did not (r=0.013, p=0.841). Conclusions: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.

Original languageEnglish
Pages (from-to)832-838
Number of pages7
JournalHepato-Gastroenterology
Volume57
Issue number101
Publication statusPublished - 2010 Jul 1

Fingerprint

Chronic Hepatitis B
Fatty Liver
Liver
Fibrosis
Regression Analysis
Liver Cirrhosis
Linear Models
Body Mass Index
Multivariate Analysis
Biopsy

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{198e8cdd5e0847c1bb6d46b2db7be5ca,
title = "The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B",
abstract = "Background/Aims: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan{\circledR} accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). Methodology: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. Results: The mean age of the patients was 44.4 years and the mean body mass index was 23.3±2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9{\%}), 37 (22.8{\%}), 17 (10.5{\%}) and 92 (56.8{\%}), respectively. Steatosis was S0 in 128 patients (79.0{\%}), Sl in 28 (17.3{\%}), S2 in 6 (3.7{\%}) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r=0.023, p=0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r=0.268, p<0.001), while steatosis did not (r=0.013, p=0.841). Conclusions: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.",
author = "Seungup Kim and doyoung kim and SangHoon Ahn and Heeman Kim and Lee, {Jung Min} and Chon, {Chae Yoon} and Park, {Young Nyun} and KwangHyub Han and Junyong Park",
year = "2010",
month = "7",
day = "1",
language = "English",
volume = "57",
pages = "832--838",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "101",

}

The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B. / Kim, Seungup; kim, doyoung; Ahn, SangHoon; Kim, Heeman; Lee, Jung Min; Chon, Chae Yoon; Park, Young Nyun; Han, KwangHyub; Park, Junyong.

In: Hepato-Gastroenterology, Vol. 57, No. 101, 01.07.2010, p. 832-838.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B

AU - Kim, Seungup

AU - kim, doyoung

AU - Ahn, SangHoon

AU - Kim, Heeman

AU - Lee, Jung Min

AU - Chon, Chae Yoon

AU - Park, Young Nyun

AU - Han, KwangHyub

AU - Park, Junyong

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Background/Aims: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan® accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). Methodology: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. Results: The mean age of the patients was 44.4 years and the mean body mass index was 23.3±2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), Sl in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r=0.023, p=0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r=0.268, p<0.001), while steatosis did not (r=0.013, p=0.841). Conclusions: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.

AB - Background/Aims: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan® accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). Methodology: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. Results: The mean age of the patients was 44.4 years and the mean body mass index was 23.3±2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), Sl in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r=0.023, p=0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r=0.268, p<0.001), while steatosis did not (r=0.013, p=0.841). Conclusions: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.

UR - http://www.scopus.com/inward/record.url?scp=78149261884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149261884&partnerID=8YFLogxK

M3 - Article

C2 - 21033238

AN - SCOPUS:78149261884

VL - 57

SP - 832

EP - 838

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 101

ER -