The impact of total antioxidant capacity on pulmonary function in asthma patients

S. Y. Yoon, T. B. Kim, S. Baek, S. Kim, H. S. Kwon, Y. S. Lee, T. Lee, A. S. Jang, Y. S. Chang, S. H. Cho, B. W. Choi, Jungwon Park, D. H. Nham, H. J. Yoon, Y. J. Cho, C. S. Park, H. B. Moon, You Sook Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

Original languageEnglish
Pages (from-to)1544-1550
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume16
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Asthma
Antioxidants
Lung
Forced Expiratory Volume
Serum
Respiratory Function Tests
Korea
Oxidants
Oxidative Stress
Body Mass Index
Biomarkers
Smoking
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Yoon, S. Y., Kim, T. B., Baek, S., Kim, S., Kwon, H. S., Lee, Y. S., ... Cho, Y. S. (2012). The impact of total antioxidant capacity on pulmonary function in asthma patients. International Journal of Tuberculosis and Lung Disease, 16(11), 1544-1550. https://doi.org/10.5588/ijtld.12.0842
Yoon, S. Y. ; Kim, T. B. ; Baek, S. ; Kim, S. ; Kwon, H. S. ; Lee, Y. S. ; Lee, T. ; Jang, A. S. ; Chang, Y. S. ; Cho, S. H. ; Choi, B. W. ; Park, Jungwon ; Nham, D. H. ; Yoon, H. J. ; Cho, Y. J. ; Park, C. S. ; Moon, H. B. ; Cho, You Sook. / The impact of total antioxidant capacity on pulmonary function in asthma patients. In: International Journal of Tuberculosis and Lung Disease. 2012 ; Vol. 16, No. 11. pp. 1544-1550.
@article{a6e960d5ea3d4af1a8b35ea5fca4a502,
title = "The impact of total antioxidant capacity on pulmonary function in asthma patients",
abstract = "BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.",
author = "Yoon, {S. Y.} and Kim, {T. B.} and S. Baek and S. Kim and Kwon, {H. S.} and Lee, {Y. S.} and T. Lee and Jang, {A. S.} and Chang, {Y. S.} and Cho, {S. H.} and Choi, {B. W.} and Jungwon Park and Nham, {D. H.} and Yoon, {H. J.} and Cho, {Y. J.} and Park, {C. S.} and Moon, {H. B.} and Cho, {You Sook}",
year = "2012",
month = "11",
day = "1",
doi = "10.5588/ijtld.12.0842",
language = "English",
volume = "16",
pages = "1544--1550",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "11",

}

Yoon, SY, Kim, TB, Baek, S, Kim, S, Kwon, HS, Lee, YS, Lee, T, Jang, AS, Chang, YS, Cho, SH, Choi, BW, Park, J, Nham, DH, Yoon, HJ, Cho, YJ, Park, CS, Moon, HB & Cho, YS 2012, 'The impact of total antioxidant capacity on pulmonary function in asthma patients', International Journal of Tuberculosis and Lung Disease, vol. 16, no. 11, pp. 1544-1550. https://doi.org/10.5588/ijtld.12.0842

The impact of total antioxidant capacity on pulmonary function in asthma patients. / Yoon, S. Y.; Kim, T. B.; Baek, S.; Kim, S.; Kwon, H. S.; Lee, Y. S.; Lee, T.; Jang, A. S.; Chang, Y. S.; Cho, S. H.; Choi, B. W.; Park, Jungwon; Nham, D. H.; Yoon, H. J.; Cho, Y. J.; Park, C. S.; Moon, H. B.; Cho, You Sook.

In: International Journal of Tuberculosis and Lung Disease, Vol. 16, No. 11, 01.11.2012, p. 1544-1550.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The impact of total antioxidant capacity on pulmonary function in asthma patients

AU - Yoon, S. Y.

AU - Kim, T. B.

AU - Baek, S.

AU - Kim, S.

AU - Kwon, H. S.

AU - Lee, Y. S.

AU - Lee, T.

AU - Jang, A. S.

AU - Chang, Y. S.

AU - Cho, S. H.

AU - Choi, B. W.

AU - Park, Jungwon

AU - Nham, D. H.

AU - Yoon, H. J.

AU - Cho, Y. J.

AU - Park, C. S.

AU - Moon, H. B.

AU - Cho, You Sook

PY - 2012/11/1

Y1 - 2012/11/1

N2 - BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

AB - BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

UR - http://www.scopus.com/inward/record.url?scp=84867220065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867220065&partnerID=8YFLogxK

U2 - 10.5588/ijtld.12.0842

DO - 10.5588/ijtld.12.0842

M3 - Article

VL - 16

SP - 1544

EP - 1550

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 11

ER -