The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease

In Young Jung, Hea Won Ann, Jung Ju Kim, Se Ju Lee, Jinnam Kim, Hye Seong, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, JunYong Choi, Young Goo Song, June Myung Kim

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Abstract

Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48% vs 67%, P = 0.008), headache (9% vs 20%, P = 0.013), bilateral lymphadenopathy (31% vs 46%, P = 0.029), thrombocytopenia (14% vs 29%, P = 0.014), elevated C-reactive protein (CRP) (35% vs 78.4%, P < 0.001), elevated liver enzymes (15% vs 41%, P < 0.001), and elevated lactate dehydrogenase (LDH) (61% vs 80%, P = 0.021). Male patients had fewer autoimmune features (9% vs 2%, P = 0.043) and fewer positive antinuclear antibodies (32% vs 10%, P = 0.006). In this study, 25.6% of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.

Original languageEnglish
Article numbere6332
JournalMedicine (United States)
Volume96
Issue number11
DOIs
Publication statusPublished - 2017 Mar 1

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Histiocytic Necrotizing Lymphadenitis
Incidence
L-Lactate Dehydrogenase
Thrombocytopenia
C-Reactive Protein
Headache
Fever
Lymph Nodes
Liver
Antinuclear Antibodies
Sex Ratio
Enzymes
Tertiary Care Centers
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jung, In Young ; Ann, Hea Won ; Kim, Jung Ju ; Lee, Se Ju ; Kim, Jinnam ; Seong, Hye ; Oh, Dong Hyun ; Kim, Yong Chan ; Kim, Eun Jin ; Jeong, Su Jin ; Ku, Nam Su ; Choi, JunYong ; Song, Young Goo ; Kim, June Myung. / The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease. In: Medicine (United States). 2017 ; Vol. 96, No. 11.
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title = "The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease",
abstract = "Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48{\%} vs 67{\%}, P = 0.008), headache (9{\%} vs 20{\%}, P = 0.013), bilateral lymphadenopathy (31{\%} vs 46{\%}, P = 0.029), thrombocytopenia (14{\%} vs 29{\%}, P = 0.014), elevated C-reactive protein (CRP) (35{\%} vs 78.4{\%}, P < 0.001), elevated liver enzymes (15{\%} vs 41{\%}, P < 0.001), and elevated lactate dehydrogenase (LDH) (61{\%} vs 80{\%}, P = 0.021). Male patients had fewer autoimmune features (9{\%} vs 2{\%}, P = 0.043) and fewer positive antinuclear antibodies (32{\%} vs 10{\%}, P = 0.006). In this study, 25.6{\%} of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.",
author = "Jung, {In Young} and Ann, {Hea Won} and Kim, {Jung Ju} and Lee, {Se Ju} and Jinnam Kim and Hye Seong and Oh, {Dong Hyun} and Kim, {Yong Chan} and Kim, {Eun Jin} and Jeong, {Su Jin} and Ku, {Nam Su} and JunYong Choi and Song, {Young Goo} and Kim, {June Myung}",
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Jung, IY, Ann, HW, Kim, JJ, Lee, SJ, Kim, J, Seong, H, Oh, DH, Kim, YC, Kim, EJ, Jeong, SJ, Ku, NS, Choi, J, Song, YG & Kim, JM 2017, 'The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease', Medicine (United States), vol. 96, no. 11, e6332. https://doi.org/10.1097/MD.0000000000006332

The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease. / Jung, In Young; Ann, Hea Won; Kim, Jung Ju; Lee, Se Ju; Kim, Jinnam; Seong, Hye; Oh, Dong Hyun; Kim, Yong Chan; Kim, Eun Jin; Jeong, Su Jin; Ku, Nam Su; Choi, JunYong; Song, Young Goo; Kim, June Myung.

In: Medicine (United States), Vol. 96, No. 11, e6332, 01.03.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease

AU - Jung, In Young

AU - Ann, Hea Won

AU - Kim, Jung Ju

AU - Lee, Se Ju

AU - Kim, Jinnam

AU - Seong, Hye

AU - Oh, Dong Hyun

AU - Kim, Yong Chan

AU - Kim, Eun Jin

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Choi, JunYong

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48% vs 67%, P = 0.008), headache (9% vs 20%, P = 0.013), bilateral lymphadenopathy (31% vs 46%, P = 0.029), thrombocytopenia (14% vs 29%, P = 0.014), elevated C-reactive protein (CRP) (35% vs 78.4%, P < 0.001), elevated liver enzymes (15% vs 41%, P < 0.001), and elevated lactate dehydrogenase (LDH) (61% vs 80%, P = 0.021). Male patients had fewer autoimmune features (9% vs 2%, P = 0.043) and fewer positive antinuclear antibodies (32% vs 10%, P = 0.006). In this study, 25.6% of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.

AB - Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48% vs 67%, P = 0.008), headache (9% vs 20%, P = 0.013), bilateral lymphadenopathy (31% vs 46%, P = 0.029), thrombocytopenia (14% vs 29%, P = 0.014), elevated C-reactive protein (CRP) (35% vs 78.4%, P < 0.001), elevated liver enzymes (15% vs 41%, P < 0.001), and elevated lactate dehydrogenase (LDH) (61% vs 80%, P = 0.021). Male patients had fewer autoimmune features (9% vs 2%, P = 0.043) and fewer positive antinuclear antibodies (32% vs 10%, P = 0.006). In this study, 25.6% of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.

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