The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis

Seung Hoon Ryang, Jae Hung Jung, Minseob Eom, Jae Mann Song, Hyun Chul Chung, Yunbyung Chae, Chang Min Lee, Kwang Jin Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to testicular germ cell tumor. Approximately 50% of patients with ITGCN will develop an invasive of testicular germ cell tumors within 5 years. Therefore, we evaluated that the incidence of ITGCN in postpubertal cryptorchidism. Materials and Methods: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertalpatients (aged 12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains of placental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin-eosin stain. Additionally, the degree of spermatogenesis was assessed using the Johnsen score. Results: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. One patient (3.2%) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesis showed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis with low Johnsen score lesser than 5. Conclusions: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains and discuss preventative orchiectomy for the postpubertal cryptorchidism.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalKorean Journal of Urology
Volume56
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Germ Cells
Testis
Cryptorchidism
Spermatogenesis
Incidence
Neoplasms
Coloring Agents
Orchiectomy
Hematoxylin
Eosine Yellowish-(YS)
Testicular Germ Cell Tumor

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Ryang, Seung Hoon ; Jung, Jae Hung ; Eom, Minseob ; Song, Jae Mann ; Chung, Hyun Chul ; Chae, Yunbyung ; Lee, Chang Min ; Kim, Kwang Jin. / The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis. In: Korean Journal of Urology. 2015 ; Vol. 56, No. 7. pp. 515-518.
@article{4d03527193244153ab9042dadf39ba28,
title = "The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis",
abstract = "Purpose: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to testicular germ cell tumor. Approximately 50{\%} of patients with ITGCN will develop an invasive of testicular germ cell tumors within 5 years. Therefore, we evaluated that the incidence of ITGCN in postpubertal cryptorchidism. Materials and Methods: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertalpatients (aged 12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains of placental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin-eosin stain. Additionally, the degree of spermatogenesis was assessed using the Johnsen score. Results: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. One patient (3.2{\%}) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesis showed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis with low Johnsen score lesser than 5. Conclusions: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains and discuss preventative orchiectomy for the postpubertal cryptorchidism.",
author = "Ryang, {Seung Hoon} and Jung, {Jae Hung} and Minseob Eom and Song, {Jae Mann} and Chung, {Hyun Chul} and Yunbyung Chae and Lee, {Chang Min} and Kim, {Kwang Jin}",
year = "2015",
month = "7",
day = "1",
doi = "10.4111/kju.2015.56.7.515",
language = "English",
volume = "56",
pages = "515--518",
journal = "Korean Journal of Urology",
issn = "2005-6737",
publisher = "Korean Urological Association",
number = "7",

}

The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis. / Ryang, Seung Hoon; Jung, Jae Hung; Eom, Minseob; Song, Jae Mann; Chung, Hyun Chul; Chae, Yunbyung; Lee, Chang Min; Kim, Kwang Jin.

In: Korean Journal of Urology, Vol. 56, No. 7, 01.07.2015, p. 515-518.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis

AU - Ryang, Seung Hoon

AU - Jung, Jae Hung

AU - Eom, Minseob

AU - Song, Jae Mann

AU - Chung, Hyun Chul

AU - Chae, Yunbyung

AU - Lee, Chang Min

AU - Kim, Kwang Jin

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Purpose: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to testicular germ cell tumor. Approximately 50% of patients with ITGCN will develop an invasive of testicular germ cell tumors within 5 years. Therefore, we evaluated that the incidence of ITGCN in postpubertal cryptorchidism. Materials and Methods: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertalpatients (aged 12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains of placental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin-eosin stain. Additionally, the degree of spermatogenesis was assessed using the Johnsen score. Results: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. One patient (3.2%) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesis showed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis with low Johnsen score lesser than 5. Conclusions: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains and discuss preventative orchiectomy for the postpubertal cryptorchidism.

AB - Purpose: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to testicular germ cell tumor. Approximately 50% of patients with ITGCN will develop an invasive of testicular germ cell tumors within 5 years. Therefore, we evaluated that the incidence of ITGCN in postpubertal cryptorchidism. Materials and Methods: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertalpatients (aged 12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains of placental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin-eosin stain. Additionally, the degree of spermatogenesis was assessed using the Johnsen score. Results: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. One patient (3.2%) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesis showed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis with low Johnsen score lesser than 5. Conclusions: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains and discuss preventative orchiectomy for the postpubertal cryptorchidism.

UR - http://www.scopus.com/inward/record.url?scp=84936998941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936998941&partnerID=8YFLogxK

U2 - 10.4111/kju.2015.56.7.515

DO - 10.4111/kju.2015.56.7.515

M3 - Article

C2 - 26175870

AN - SCOPUS:84936998941

VL - 56

SP - 515

EP - 518

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 7

ER -