The Incidence of Cardiovascular Events Is Comparable between Normoalbuminuric and Albuminuric Diabetic Patients with Chronic Kidney Disease

Eunyoung Lee, Hyung Jung Oh, Jung Tak Park, SeungHyeok Han, Dong Ryeol Ryu, Shin-Wook Kang, TaeHyun Yoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diabetic kidney disease leads to microalbuminuria and gradually progresses to overt proteinuria with renal insufficiency. Recent studies have demonstrated that 20% to 40% of patients with diabetic kidney disease are normo-to microalbuminuric, despite reduced renal function. We investigated renal and cardiovascular outcomes in patients with diabetes and renal insufficiency who were normo-, micro-, and macroalbuminuric. Patients with diabetes and stage III or IV chronic kidney disease were recruited and divided into normoalbuminuric, microalbuminuric, and macroalbuminuric groups. New-onset cardiovascular events and renal outcomes, defined by end-stage renal disease or a 50% decline in estimated glomerular filtration rate, were evaluated. Among the 1136 study patients, 255 (22.4%) were normoalbuminuric. During a mean follow-up duration of 44 months, the incidence of cardiovascular disease was similar among groups (P=0.68). However, renal outcomes were significantly more common in patients with macroalbuminuria than in those who were normoalbuminuric or microalbuminuric (P<0.001). Multivariate Cox analysis identified macroalbuminuria and estimated glomerular filtration rate as independent predictors of renal outcomes. The amount of albuminuria was not associated with cardiovascular events in this population. Although cardiovascular events were similar in patients with diabetic kidney disease and renal insufficiency, renal outcomes differed significantly according to the amount of albuminuria.

Original languageEnglish
Article numbere3175
JournalMedicine (United States)
Volume95
Issue number15
DOIs
Publication statusPublished - 2016 Apr 1

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Chronic Renal Insufficiency
Kidney
Renal Insufficiency
Incidence
Diabetic Nephropathies
Albuminuria
Glomerular Filtration Rate
Proteinuria
Chronic Kidney Failure
Cardiovascular Diseases
Multivariate Analysis
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Diabetic kidney disease leads to microalbuminuria and gradually progresses to overt proteinuria with renal insufficiency. Recent studies have demonstrated that 20{\%} to 40{\%} of patients with diabetic kidney disease are normo-to microalbuminuric, despite reduced renal function. We investigated renal and cardiovascular outcomes in patients with diabetes and renal insufficiency who were normo-, micro-, and macroalbuminuric. Patients with diabetes and stage III or IV chronic kidney disease were recruited and divided into normoalbuminuric, microalbuminuric, and macroalbuminuric groups. New-onset cardiovascular events and renal outcomes, defined by end-stage renal disease or a 50{\%} decline in estimated glomerular filtration rate, were evaluated. Among the 1136 study patients, 255 (22.4{\%}) were normoalbuminuric. During a mean follow-up duration of 44 months, the incidence of cardiovascular disease was similar among groups (P=0.68). However, renal outcomes were significantly more common in patients with macroalbuminuria than in those who were normoalbuminuric or microalbuminuric (P<0.001). Multivariate Cox analysis identified macroalbuminuria and estimated glomerular filtration rate as independent predictors of renal outcomes. The amount of albuminuria was not associated with cardiovascular events in this population. Although cardiovascular events were similar in patients with diabetic kidney disease and renal insufficiency, renal outcomes differed significantly according to the amount of albuminuria.",
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The Incidence of Cardiovascular Events Is Comparable between Normoalbuminuric and Albuminuric Diabetic Patients with Chronic Kidney Disease. / Lee, Eunyoung; Oh, Hyung Jung; Park, Jung Tak; Han, SeungHyeok; Ryu, Dong Ryeol; Kang, Shin-Wook; Yoo, TaeHyun.

In: Medicine (United States), Vol. 95, No. 15, e3175, 01.04.2016.

Research output: Contribution to journalArticle

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AU - Yoo, TaeHyun

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