The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30 + anaplastic large cell lymphoma in Korea

You Chan Kim, Woo Ick Yang, Mingeol Lee, Sang Gun Park, Soo Nam Kim, Kwang Hyun Cho, Seok Jong Lee, Mi Woo Lee, Jai Kyoung Koh

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Abstract

Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30 + anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30 + ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30 + ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30 + ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30 + ALCL are unlikely to be associated with EBV, however, systemic CD30 + ALCL may be associated with EBV.

Original languageEnglish
Pages (from-to)1596-1602
Number of pages7
JournalKorean Journal of Dermatology
Volume43
Issue number12
Publication statusPublished - 2005 Dec 1

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Lymphomatoid Papulosis
Anaplastic Large-Cell Lymphoma
Korea
Human Herpesvirus 4
Skin
Incidence
RNA
In Situ Hybridization
Primary Cutaneous Anaplastic Large Cell Lymphoma
Viral Matrix Proteins
Lymph Nodes
Paraffin
Formaldehyde
Membrane Proteins
Spleen

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, You Chan ; Yang, Woo Ick ; Lee, Mingeol ; Park, Sang Gun ; Kim, Soo Nam ; Cho, Kwang Hyun ; Lee, Seok Jong ; Lee, Mi Woo ; Koh, Jai Kyoung. / The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30 + anaplastic large cell lymphoma in Korea In: Korean Journal of Dermatology. 2005 ; Vol. 43, No. 12. pp. 1596-1602.
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title = "The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30 + anaplastic large cell lymphoma in Korea",
abstract = "Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30 + anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30 + ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30 + ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30 + ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30 + ALCL are unlikely to be associated with EBV, however, systemic CD30 + ALCL may be associated with EBV.",
author = "Kim, {You Chan} and Yang, {Woo Ick} and Mingeol Lee and Park, {Sang Gun} and Kim, {Soo Nam} and Cho, {Kwang Hyun} and Lee, {Seok Jong} and Lee, {Mi Woo} and Koh, {Jai Kyoung}",
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The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30 + anaplastic large cell lymphoma in Korea . / Kim, You Chan; Yang, Woo Ick; Lee, Mingeol; Park, Sang Gun; Kim, Soo Nam; Cho, Kwang Hyun; Lee, Seok Jong; Lee, Mi Woo; Koh, Jai Kyoung.

In: Korean Journal of Dermatology, Vol. 43, No. 12, 01.12.2005, p. 1596-1602.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30 + anaplastic large cell lymphoma in Korea

AU - Kim, You Chan

AU - Yang, Woo Ick

AU - Lee, Mingeol

AU - Park, Sang Gun

AU - Kim, Soo Nam

AU - Cho, Kwang Hyun

AU - Lee, Seok Jong

AU - Lee, Mi Woo

AU - Koh, Jai Kyoung

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30 + anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30 + ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30 + ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30 + ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30 + ALCL are unlikely to be associated with EBV, however, systemic CD30 + ALCL may be associated with EBV.

AB - Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30 + anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30 + ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30 + ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30 + ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30 + ALCL are unlikely to be associated with EBV, however, systemic CD30 + ALCL may be associated with EBV.

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M3 - Article

VL - 43

SP - 1596

EP - 1602

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

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