Abstract
Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30+ ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30+ ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30+ ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30+ ALCL are unlikely to be associated with EBV, however, systemic CD30+ ALCL may be associated with EBV.
| Original language | English |
|---|---|
| Pages (from-to) | 1596-1602 |
| Number of pages | 7 |
| Journal | Korean Journal of Dermatology |
| Volume | 43 |
| Issue number | 12 |
| Publication status | Published - 2005 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30+ anaplastic large cell lymphoma in Korea. / Kim, You Chan; Yang, Woo Ick; Lee, Min Geol; Park, Sang Gun; Kim, Soo Nam; Cho, Kwang Hyun; Lee, Seok Jong; Lee, Mi Woo; Koh, Jai Kyoung.
In: Korean Journal of Dermatology, Vol. 43, No. 12, 01.12.2005, p. 1596-1602.Research output: Contribution to journal › Article
TY - JOUR
T1 - The incidence of the expression of Epstein-Barr virus in lymphomatoid papulosis and cutaneous CD30+ anaplastic large cell lymphoma in Korea
AU - Kim, You Chan
AU - Yang, Woo Ick
AU - Lee, Min Geol
AU - Park, Sang Gun
AU - Kim, Soo Nam
AU - Cho, Kwang Hyun
AU - Lee, Seok Jong
AU - Lee, Mi Woo
AU - Koh, Jai Kyoung
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30+ ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30+ ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30+ ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30+ ALCL are unlikely to be associated with EBV, however, systemic CD30+ ALCL may be associated with EBV.
AB - Background: The frequency of Epstein-Barr virus (EBV) in T-cell tumors has been shown to be higher in the Asian compared to the Western population. However, data on the expression of EBV in lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL) in Korea is limited. Objectives: The aim of this study was to evaluate the expression of EBV in LyP and cutaneous CD30+ ALCL in Korea. Method: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry, including viral latent membrane protein-1 (LMP-1), were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving skin which were collected from 6 university hospital medical centers in Korea. Results: In situ hybridization studies revealed positivity of the neoplastic cells for EBER in 2 of 16 specimens of CD30+ ALCL and in none of the LyP specimens. One EBER-positive case was cutaneous CD30+ ALCL with concurrent involvement of lymph nodes. The other case was CD30 + ALCL involving skin and other organs such as lymph nodes, bone, lung, and the spleen. Immunostaining for LMP-1 was also positive only for the 2 cases of EBER-positive CD30+ ALCL. Conclusion: In Korea, LyP and primary cutaneous CD30+ ALCL are unlikely to be associated with EBV, however, systemic CD30+ ALCL may be associated with EBV.
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M3 - Article
AN - SCOPUS:33644767988
VL - 43
SP - 1596
EP - 1602
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
SN - 0494-4739
IS - 12
ER -