The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes

Seok Kang Eun, Young Park So, Jin Kim Hyeong, Woo Ahn Chul, Moonsuk Nam, Soo Cha Bong, Kil Lim Sung, Rae Kim Kyung, Chul Lee Hyun

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Abstract

OBJECTIVE - The aim of this study was to examine the effects of rosiglitazone on adiponectin and plasma glucose levels in relation with common adiponectin gene (ACDC) polymorphisms. RESEARCH DESIGN AND METHODS - A total of 166 patients with type 2 diabetes were treated with rosiglitazone (4 mg/day) for 12 weeks without changing any of their previous medications. In all, single nucleotide polymorphism (SNP)45 and SNP276 of ACDC were examined. RESULTS - Regarding SNP45, there was a smaller reduction in the fasting plasma glucose (FPG) level and the HbA1c value in the carriers of the GG genotype than in the carriers of the other genotypes (P = 0.031 and 0.013, respectively). There was a smaller increase in the serum adiponectin concentration for the GG genotype than for the other genotypes (P = 0.003). Regarding SNP276, there was less reduction in the FPG level for the GG genotype than for the other genotypes (P = 0.001). In the haplotype analysis, the reductions in the FPG and HbA 1c levels were smaller for the GG homozygote haplotype than for the other haplotypes (P = 0.001 and 0.001, respectively). The increase in the plasma adiponectin concentration for the GG homozygots haplotype was smaller than that of the other haplotypes (P = 0.003). CONCLUSIONS - These data suggest that genetic variations in the adiponectin gene can affect the resiglitazone treatment response of the circulating adiponectin level and blood glucose control in type 2 diabetic patients.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalDiabetes Care
Volume28
Issue number5
DOIs
Publication statusPublished - 2005 May 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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    Eun, S. K., So, Y. P., Hyeong, J. K., Chul, W. A., Nam, M., Bong, S. C., Sung, K. L., Kyung, R. K., & Hyun, C. L. (2005). The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes. Diabetes Care, 28(5), 1139-1144. https://doi.org/10.2337/diacare.28.5.1139