The influence of age and prostate volume on the cancer detection rate in Korean men with PSA levels of 4.0 to 10.0ng/ml: A multicenter, retrospective study

Do Hwan Seong, Jin Seon Cho, Sung Joon Hong, Byung Ha Chung, Y. Deuk Choi, Se Joong Kim, Dong Hyeon Lee, In Rae Cho, Young Sik Kim, Chun Il Kim, Sun Il Kim, Jae Man Song, Sang Hyeon Cheon, Hong Sup Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml. Materials and methods: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies (TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Results: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5%). The mean age (cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD (0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate (20.1%) in the small prostate (less than 40ml) was significantly higher than that (10.3%) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4% for the 50 to 59 year-old patients to 31.6% for the 80 or more year-old patients. Conclusions: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalKorean Journal of Urology
Volume47
Issue number4
DOIs
Publication statusPublished - 2006 Apr

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Prostate-Specific Antigen
Multicenter Studies
Prostate
Retrospective Studies
Neoplasms
Biopsy
Prostatic Neoplasms
Age Groups

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Seong, Do Hwan ; Cho, Jin Seon ; Hong, Sung Joon ; Chung, Byung Ha ; Choi, Y. Deuk ; Kim, Se Joong ; Lee, Dong Hyeon ; Cho, In Rae ; Kim, Young Sik ; Kim, Chun Il ; Kim, Sun Il ; Song, Jae Man ; Cheon, Sang Hyeon ; Kim, Hong Sup. / The influence of age and prostate volume on the cancer detection rate in Korean men with PSA levels of 4.0 to 10.0ng/ml : A multicenter, retrospective study. In: Korean Journal of Urology. 2006 ; Vol. 47, No. 4. pp. 353-357.
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title = "The influence of age and prostate volume on the cancer detection rate in Korean men with PSA levels of 4.0 to 10.0ng/ml: A multicenter, retrospective study",
abstract = "Purpose: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml. Materials and methods: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies (TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Results: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5{\%}). The mean age (cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD (0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate (20.1{\%}) in the small prostate (less than 40ml) was significantly higher than that (10.3{\%}) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4{\%} for the 50 to 59 year-old patients to 31.6{\%} for the 80 or more year-old patients. Conclusions: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed.",
author = "Seong, {Do Hwan} and Cho, {Jin Seon} and Hong, {Sung Joon} and Chung, {Byung Ha} and Choi, {Y. Deuk} and Kim, {Se Joong} and Lee, {Dong Hyeon} and Cho, {In Rae} and Kim, {Young Sik} and Kim, {Chun Il} and Kim, {Sun Il} and Song, {Jae Man} and Cheon, {Sang Hyeon} and Kim, {Hong Sup}",
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The influence of age and prostate volume on the cancer detection rate in Korean men with PSA levels of 4.0 to 10.0ng/ml : A multicenter, retrospective study. / Seong, Do Hwan; Cho, Jin Seon; Hong, Sung Joon; Chung, Byung Ha; Choi, Y. Deuk; Kim, Se Joong; Lee, Dong Hyeon; Cho, In Rae; Kim, Young Sik; Kim, Chun Il; Kim, Sun Il; Song, Jae Man; Cheon, Sang Hyeon; Kim, Hong Sup.

In: Korean Journal of Urology, Vol. 47, No. 4, 04.2006, p. 353-357.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The influence of age and prostate volume on the cancer detection rate in Korean men with PSA levels of 4.0 to 10.0ng/ml

T2 - A multicenter, retrospective study

AU - Seong, Do Hwan

AU - Cho, Jin Seon

AU - Hong, Sung Joon

AU - Chung, Byung Ha

AU - Choi, Y. Deuk

AU - Kim, Se Joong

AU - Lee, Dong Hyeon

AU - Cho, In Rae

AU - Kim, Young Sik

AU - Kim, Chun Il

AU - Kim, Sun Il

AU - Song, Jae Man

AU - Cheon, Sang Hyeon

AU - Kim, Hong Sup

PY - 2006/4

Y1 - 2006/4

N2 - Purpose: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml. Materials and methods: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies (TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Results: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5%). The mean age (cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD (0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate (20.1%) in the small prostate (less than 40ml) was significantly higher than that (10.3%) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4% for the 50 to 59 year-old patients to 31.6% for the 80 or more year-old patients. Conclusions: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed.

AB - Purpose: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml. Materials and methods: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies (TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Results: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5%). The mean age (cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD (0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate (20.1%) in the small prostate (less than 40ml) was significantly higher than that (10.3%) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4% for the 50 to 59 year-old patients to 31.6% for the 80 or more year-old patients. Conclusions: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed.

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U2 - 10.4111/kju.2006.47.4.353

DO - 10.4111/kju.2006.47.4.353

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VL - 47

SP - 353

EP - 357

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 4

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