The influence of age on survival and recurrence after a curative surgical resection for colon cancer patients

Cho Rok Lee, Young Wan Kim, Nam Kyu Kim, Hyuk Hur, Byung Soh Min, Kang Young Lee, Seung Kook Sohn, Chang Hwan Cho

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: This study was performed to evaluate whether age was a factor associated with oncological outcome for colon cancer patients who underwent a curative surgical resection. Methods: A retrospective study of 2,125 colon cancer patients who underwent surgery between January 1989 to December 2004 was conducted. Results: Of the 2,125 patients, 1,724 patients underwent a curative resection (RO). The patients with RO were classified into three groups: group I (n=142) under 40 yr of age, group II (n=1,462) between 40 and 75 yr of age, and group III (n=120) over 75 yr of age. There were no significant differences in gender, tumor diameter, or postoperative complications among the groups. A history of hereditary colon cancer, advanced TNM stage (III, IV), and poorly- differentiated histology were more commonly found in group I. Adjuvant chemotherapy was administered less frequently in group III. In the survival analysis, the cancer-specific survival (CSS) and the disease-free survival (DFS) rates were not different between groups I and II. The CSS and the DFS rates of group III were significantly unfavorable compared with those of groups I and II. On the multivariate analysis, old age (group III), TNM stage, and preoperative CEA level were independent risk factors for CSS and DFS. Conclusion: In colon cancer patients, tailored approaches according to age, such as early screening in young adults with family history and proper patients selection for adjuvant treatment in old patients, could be needed.

Original languageEnglish
Pages (from-to)401-409
Number of pages9
JournalJournal of the Korean Society of Coloproctology
Volume25
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1

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Colonic Neoplasms
Recurrence
Survival
Disease-Free Survival
Age Groups
Patient Selection
Neoplasms
Survival Rate
Adjuvant Chemotherapy
Survival Analysis
Young Adult
Histology
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Lee, Cho Rok ; Kim, Young Wan ; Kim, Nam Kyu ; Hur, Hyuk ; Min, Byung Soh ; Lee, Kang Young ; Sohn, Seung Kook ; Cho, Chang Hwan. / The influence of age on survival and recurrence after a curative surgical resection for colon cancer patients. In: Journal of the Korean Society of Coloproctology. 2009 ; Vol. 25, No. 6. pp. 401-409.
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The influence of age on survival and recurrence after a curative surgical resection for colon cancer patients. / Lee, Cho Rok; Kim, Young Wan; Kim, Nam Kyu; Hur, Hyuk; Min, Byung Soh; Lee, Kang Young; Sohn, Seung Kook; Cho, Chang Hwan.

In: Journal of the Korean Society of Coloproctology, Vol. 25, No. 6, 01.12.2009, p. 401-409.

Research output: Contribution to journalArticle

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T1 - The influence of age on survival and recurrence after a curative surgical resection for colon cancer patients

AU - Lee, Cho Rok

AU - Kim, Young Wan

AU - Kim, Nam Kyu

AU - Hur, Hyuk

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AU - Lee, Kang Young

AU - Sohn, Seung Kook

AU - Cho, Chang Hwan

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N2 - Purpose: This study was performed to evaluate whether age was a factor associated with oncological outcome for colon cancer patients who underwent a curative surgical resection. Methods: A retrospective study of 2,125 colon cancer patients who underwent surgery between January 1989 to December 2004 was conducted. Results: Of the 2,125 patients, 1,724 patients underwent a curative resection (RO). The patients with RO were classified into three groups: group I (n=142) under 40 yr of age, group II (n=1,462) between 40 and 75 yr of age, and group III (n=120) over 75 yr of age. There were no significant differences in gender, tumor diameter, or postoperative complications among the groups. A history of hereditary colon cancer, advanced TNM stage (III, IV), and poorly- differentiated histology were more commonly found in group I. Adjuvant chemotherapy was administered less frequently in group III. In the survival analysis, the cancer-specific survival (CSS) and the disease-free survival (DFS) rates were not different between groups I and II. The CSS and the DFS rates of group III were significantly unfavorable compared with those of groups I and II. On the multivariate analysis, old age (group III), TNM stage, and preoperative CEA level were independent risk factors for CSS and DFS. Conclusion: In colon cancer patients, tailored approaches according to age, such as early screening in young adults with family history and proper patients selection for adjuvant treatment in old patients, could be needed.

AB - Purpose: This study was performed to evaluate whether age was a factor associated with oncological outcome for colon cancer patients who underwent a curative surgical resection. Methods: A retrospective study of 2,125 colon cancer patients who underwent surgery between January 1989 to December 2004 was conducted. Results: Of the 2,125 patients, 1,724 patients underwent a curative resection (RO). The patients with RO were classified into three groups: group I (n=142) under 40 yr of age, group II (n=1,462) between 40 and 75 yr of age, and group III (n=120) over 75 yr of age. There were no significant differences in gender, tumor diameter, or postoperative complications among the groups. A history of hereditary colon cancer, advanced TNM stage (III, IV), and poorly- differentiated histology were more commonly found in group I. Adjuvant chemotherapy was administered less frequently in group III. In the survival analysis, the cancer-specific survival (CSS) and the disease-free survival (DFS) rates were not different between groups I and II. The CSS and the DFS rates of group III were significantly unfavorable compared with those of groups I and II. On the multivariate analysis, old age (group III), TNM stage, and preoperative CEA level were independent risk factors for CSS and DFS. Conclusion: In colon cancer patients, tailored approaches according to age, such as early screening in young adults with family history and proper patients selection for adjuvant treatment in old patients, could be needed.

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