The influence of body mass index at diagnosis on cognitive decline in parkinson’s disease

Han Soo Yoo, Seok Jong Chung, Phil Hyu Lee, Young H. Sohn, Suk Yun Kang

Research output: Contribution to journalArticle

Abstract

Background and Purpose Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson’s disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia. Methods We recruited 70 patients with de novo PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three groups based on their BMI at the diagnosis: under-/normal weight (n=21), overweight (n=22), and obese (n=27). We evaluated differences in the rate of cognitive decline over time among the groups using linear mixed models and the conversion rate to dementia using survival analysis. Results The obese patients with PD showed a slower deterioration of global cognitive function as well as language and memory functions than did the under-/normal-weight group during the 6-year follow-up. The three BMI groups showed different rates of conversion to dementia (log-rank test: p=0.026). The combined overweight and obese group showed a lower risk of developing dementia compared with the under-/normal-weight group (hazard ratio= 0.36, 95% CI=0.12–0.82, p=0.046). Conclusions We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia.

Original languageEnglish
Pages (from-to)517-526
Number of pages10
JournalJournal of Clinical Neurology (Korea)
Volume15
Issue number4
DOIs
Publication statusPublished - 2019 Oct

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Parkinson Disease
Dementia
Body Mass Index
Cognition
Weights and Measures
Survival Analysis
Linear Models
Language
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Yoo, Han Soo ; Chung, Seok Jong ; Lee, Phil Hyu ; Sohn, Young H. ; Kang, Suk Yun. / The influence of body mass index at diagnosis on cognitive decline in parkinson’s disease. In: Journal of Clinical Neurology (Korea). 2019 ; Vol. 15, No. 4. pp. 517-526.
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The influence of body mass index at diagnosis on cognitive decline in parkinson’s disease. / Yoo, Han Soo; Chung, Seok Jong; Lee, Phil Hyu; Sohn, Young H.; Kang, Suk Yun.

In: Journal of Clinical Neurology (Korea), Vol. 15, No. 4, 10.2019, p. 517-526.

Research output: Contribution to journalArticle

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