The influence of diabetes mellitus on periodontal tissues

A pilot study

Yoo Jung Um, Ui-Won Jung, ChangSung Kim, Eun Jung Bak, JeongHeon Cha, Yun Jung Yoo, Seongho Choi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to preliminarily evaluate the influence of diabetes mellitus (DM) on periodontal tissue without establishment of periodontitis. Methods: Seven-week-old db/db mice were used for the diabetic experimental group and systematically healthy mice of the same age were used as controls. After 1 week of acclimatization, the animals were sacrificed for hard and soft tissue evaluation. The pattern of bone destruction was evaluated by stereomicroscope evaluation with alizarin red staining and radiographic evaluation by microscopic computerized tomography images. Histological evaluation was performed with hematoxylin and eosin stain for evaluation of soft tissue changes. Results: In both stereomicroscope evaluation and radiograph image analysis, aggressive form of bone destruction was observed in diabetic animals when compared to the systematically healthy controls. In histological evaluation, apical migration of junctional epithelium with slight inflammatory cell infiltration was observed with disarrangement of connective tissue fibers. Conclusions: Within the limits of this study, diabetic animals presented distortion in periodontal attachment and an aggressive bone loss pattern when compared to the healthy controls, suggesting that DM has an independent effect on periodontal tissue destruction irrespective of the presence or absence of periodontal disease.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Periodontal and Implant Science
Volume40
Issue number2
DOIs
Publication statusPublished - 2010 Apr 1

Fingerprint

Diabetes Mellitus
Bone and Bones
Epithelial Attachment
Periodontitis
Acclimatization
Periodontal Diseases
Hematoxylin
Eosine Yellowish-(YS)
Connective Tissue
Coloring Agents
Tomography
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

Cite this

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title = "The influence of diabetes mellitus on periodontal tissues: A pilot study",
abstract = "Purpose: The purpose of this study was to preliminarily evaluate the influence of diabetes mellitus (DM) on periodontal tissue without establishment of periodontitis. Methods: Seven-week-old db/db mice were used for the diabetic experimental group and systematically healthy mice of the same age were used as controls. After 1 week of acclimatization, the animals were sacrificed for hard and soft tissue evaluation. The pattern of bone destruction was evaluated by stereomicroscope evaluation with alizarin red staining and radiographic evaluation by microscopic computerized tomography images. Histological evaluation was performed with hematoxylin and eosin stain for evaluation of soft tissue changes. Results: In both stereomicroscope evaluation and radiograph image analysis, aggressive form of bone destruction was observed in diabetic animals when compared to the systematically healthy controls. In histological evaluation, apical migration of junctional epithelium with slight inflammatory cell infiltration was observed with disarrangement of connective tissue fibers. Conclusions: Within the limits of this study, diabetic animals presented distortion in periodontal attachment and an aggressive bone loss pattern when compared to the healthy controls, suggesting that DM has an independent effect on periodontal tissue destruction irrespective of the presence or absence of periodontal disease.",
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The influence of diabetes mellitus on periodontal tissues : A pilot study. / Um, Yoo Jung; Jung, Ui-Won; Kim, ChangSung; Bak, Eun Jung; Cha, JeongHeon; Yoo, Yun Jung; Choi, Seongho.

In: Journal of Periodontal and Implant Science, Vol. 40, No. 2, 01.04.2010, p. 49-55.

Research output: Contribution to journalArticle

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AU - Um, Yoo Jung

AU - Jung, Ui-Won

AU - Kim, ChangSung

AU - Bak, Eun Jung

AU - Cha, JeongHeon

AU - Yoo, Yun Jung

AU - Choi, Seongho

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