The initial extent of malapposition in st elevation myocardial infarction treated with drug-eluting stent: The usefulness of optical coherence tomography

Ung Kim, Jung Sun Kim, Jin Sun Kim, Jung Myung Lee, Jung Woo Son, Jaedeok Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: The aim of this study is to identify the extent of initial malapposition using optical coherence tomography (OCT) in ST-elevation myocardial infarctions (STEMI) treated with different types of drug-eluting stents (DES). Materials and Methods: Twenty four STEMI patients that underwent primary percutaneous coronary intervention (PCI) were enrolled. The OCT and intravascular ultrasound (IVUS) were performed within 72 hours after the primary PCI. Distances between the endo-luminal surface of the strut reflection and the vessel wall and the extent of malapposition were measured and analyzed. Results: Sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES) and zotarolimus-eluting stents (ZES) were deployed in 7 patients (29%), 7 patients (29%) and 10 patients (42%). In total, 4951 struts in 620 mm single-stent segments were analyzed (1463 struts in SES, 1522 in PES, and 1966 in ZES). In strut analysis by OCT, the incidence of malapposition was 17% (860/4951) and in stent analysis by IVUS, malapposition rate was 21% (5/24). The malapposition rate of strut level using OCT in 5 patients who had malapposition in IVUS was significantly higher than the 19 of those who had not (32 ± 5% vs. 12 ± 6%, p = 0.001). In addition, the frequency of malapposition was also significantly different (28% in SES, 11% in PES, 10% in ZES, p = 0.001). The use of SES was an independent predictor of malapposed struts. Conclusion: The incidence of malapposition using OCT was quite prevalent in STEMI after primary PCI with DES implantation and SES has especially higher rates of malapposition compared to other DESs.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalYonsei medical journal
Volume51
Issue number3
DOIs
Publication statusPublished - 2010 May 1

Fingerprint

Drug-Eluting Stents
Optical Coherence Tomography
Stents
Myocardial Infarction
Sirolimus
Percutaneous Coronary Intervention
Paclitaxel
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Ung ; Kim, Jung Sun ; Kim, Jin Sun ; Lee, Jung Myung ; Son, Jung Woo ; Kim, Jaedeok ; Ko, Young Guk ; Choi, Donghoon ; Jang, Yangsoo. / The initial extent of malapposition in st elevation myocardial infarction treated with drug-eluting stent : The usefulness of optical coherence tomography. In: Yonsei medical journal. 2010 ; Vol. 51, No. 3. pp. 332-338.
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title = "The initial extent of malapposition in st elevation myocardial infarction treated with drug-eluting stent: The usefulness of optical coherence tomography",
abstract = "Purpose: The aim of this study is to identify the extent of initial malapposition using optical coherence tomography (OCT) in ST-elevation myocardial infarctions (STEMI) treated with different types of drug-eluting stents (DES). Materials and Methods: Twenty four STEMI patients that underwent primary percutaneous coronary intervention (PCI) were enrolled. The OCT and intravascular ultrasound (IVUS) were performed within 72 hours after the primary PCI. Distances between the endo-luminal surface of the strut reflection and the vessel wall and the extent of malapposition were measured and analyzed. Results: Sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES) and zotarolimus-eluting stents (ZES) were deployed in 7 patients (29{\%}), 7 patients (29{\%}) and 10 patients (42{\%}). In total, 4951 struts in 620 mm single-stent segments were analyzed (1463 struts in SES, 1522 in PES, and 1966 in ZES). In strut analysis by OCT, the incidence of malapposition was 17{\%} (860/4951) and in stent analysis by IVUS, malapposition rate was 21{\%} (5/24). The malapposition rate of strut level using OCT in 5 patients who had malapposition in IVUS was significantly higher than the 19 of those who had not (32 ± 5{\%} vs. 12 ± 6{\%}, p = 0.001). In addition, the frequency of malapposition was also significantly different (28{\%} in SES, 11{\%} in PES, 10{\%} in ZES, p = 0.001). The use of SES was an independent predictor of malapposed struts. Conclusion: The incidence of malapposition using OCT was quite prevalent in STEMI after primary PCI with DES implantation and SES has especially higher rates of malapposition compared to other DESs.",
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The initial extent of malapposition in st elevation myocardial infarction treated with drug-eluting stent : The usefulness of optical coherence tomography. / Kim, Ung; Kim, Jung Sun; Kim, Jin Sun; Lee, Jung Myung; Son, Jung Woo; Kim, Jaedeok; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo.

In: Yonsei medical journal, Vol. 51, No. 3, 01.05.2010, p. 332-338.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The initial extent of malapposition in st elevation myocardial infarction treated with drug-eluting stent

T2 - The usefulness of optical coherence tomography

AU - Kim, Ung

AU - Kim, Jung Sun

AU - Kim, Jin Sun

AU - Lee, Jung Myung

AU - Son, Jung Woo

AU - Kim, Jaedeok

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

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N2 - Purpose: The aim of this study is to identify the extent of initial malapposition using optical coherence tomography (OCT) in ST-elevation myocardial infarctions (STEMI) treated with different types of drug-eluting stents (DES). Materials and Methods: Twenty four STEMI patients that underwent primary percutaneous coronary intervention (PCI) were enrolled. The OCT and intravascular ultrasound (IVUS) were performed within 72 hours after the primary PCI. Distances between the endo-luminal surface of the strut reflection and the vessel wall and the extent of malapposition were measured and analyzed. Results: Sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES) and zotarolimus-eluting stents (ZES) were deployed in 7 patients (29%), 7 patients (29%) and 10 patients (42%). In total, 4951 struts in 620 mm single-stent segments were analyzed (1463 struts in SES, 1522 in PES, and 1966 in ZES). In strut analysis by OCT, the incidence of malapposition was 17% (860/4951) and in stent analysis by IVUS, malapposition rate was 21% (5/24). The malapposition rate of strut level using OCT in 5 patients who had malapposition in IVUS was significantly higher than the 19 of those who had not (32 ± 5% vs. 12 ± 6%, p = 0.001). In addition, the frequency of malapposition was also significantly different (28% in SES, 11% in PES, 10% in ZES, p = 0.001). The use of SES was an independent predictor of malapposed struts. Conclusion: The incidence of malapposition using OCT was quite prevalent in STEMI after primary PCI with DES implantation and SES has especially higher rates of malapposition compared to other DESs.

AB - Purpose: The aim of this study is to identify the extent of initial malapposition using optical coherence tomography (OCT) in ST-elevation myocardial infarctions (STEMI) treated with different types of drug-eluting stents (DES). Materials and Methods: Twenty four STEMI patients that underwent primary percutaneous coronary intervention (PCI) were enrolled. The OCT and intravascular ultrasound (IVUS) were performed within 72 hours after the primary PCI. Distances between the endo-luminal surface of the strut reflection and the vessel wall and the extent of malapposition were measured and analyzed. Results: Sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES) and zotarolimus-eluting stents (ZES) were deployed in 7 patients (29%), 7 patients (29%) and 10 patients (42%). In total, 4951 struts in 620 mm single-stent segments were analyzed (1463 struts in SES, 1522 in PES, and 1966 in ZES). In strut analysis by OCT, the incidence of malapposition was 17% (860/4951) and in stent analysis by IVUS, malapposition rate was 21% (5/24). The malapposition rate of strut level using OCT in 5 patients who had malapposition in IVUS was significantly higher than the 19 of those who had not (32 ± 5% vs. 12 ± 6%, p = 0.001). In addition, the frequency of malapposition was also significantly different (28% in SES, 11% in PES, 10% in ZES, p = 0.001). The use of SES was an independent predictor of malapposed struts. Conclusion: The incidence of malapposition using OCT was quite prevalent in STEMI after primary PCI with DES implantation and SES has especially higher rates of malapposition compared to other DESs.

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