The interaction between neighborhood disadvantage and genetic factors in the prediction of antisocial outcomes

Kevin M. Beaver, Chris L. Gibson, Matt DeLisi, Michael G. Vaughn, John Paul Wright

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Objective. There is growing recognition that antisocial behaviors are produced by a combination of environmental and genetic factors. Research has revealed that environmental and genetic factors work interactively and often moderate the effects of the other. Method. We test for gene-environment interactions in the current study by examining whether neighborhood disadvantage interacts with two dopamine receptor genes (DRD2 and DRD4) to predict three different antisocial measures: adolescent victimization, contact with delinquent peers, and involvement in violent delinquency. Results. Analysis of male respondents drawn from the National Longitudinal Study of Adolescent Health revealed that the association between the two dopamine genes and the measures of antisocial outcomes tended to be stronger in disadvantaged neighborhoods. Conclusions. Antisocial outcomes appear to be affected by gene-environment interactions between dopaminergic genes and neighborhood disadvantage.

Original languageEnglish
Pages (from-to)25-40
Number of pages16
JournalYouth Violence and Juvenile Justice
Issue number1
Publication statusPublished - 2012 Jan

Bibliographical note

Funding Information:
This research uses data from Add Health, a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle for assistance in the original design. Information on how to obtain the Add Health data files is available on the Add Health website ( ). No direct support was received from grant P01-HD31921 for this analysis.

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Developmental and Educational Psychology
  • Law


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