The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity

J. Park, T. Seo, S. Hwang, D. Lee, Y. Gwack, J. Choe

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53.

Original languageEnglish
Pages (from-to)11977-11982
Number of pages6
JournalJournal of Virology
Volume74
Issue number24
DOIs
Publication statusPublished - 2000 Dec 1

Fingerprint

Human herpesvirus 8
Basic-Leucine Zipper Transcription Factors
Human Herpesvirus 8
transcription factors
Leucine Zippers
leucine zipper
Kaposi's Sarcoma
sarcoma
Open Reading Frames
open reading frames
cell death
Cell Death
Transcription Factors
pathogenesis
apoptosis
Apoptosis
Amino Acids
amino acids
Proteins
proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Park, J. ; Seo, T. ; Hwang, S. ; Lee, D. ; Gwack, Y. ; Choe, J. / The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. In: Journal of Virology. 2000 ; Vol. 74, No. 24. pp. 11977-11982.
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The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. / Park, J.; Seo, T.; Hwang, S.; Lee, D.; Gwack, Y.; Choe, J.

In: Journal of Virology, Vol. 74, No. 24, 01.12.2000, p. 11977-11982.

Research output: Contribution to journalArticle

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T1 - The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity

AU - Park, J.

AU - Seo, T.

AU - Hwang, S.

AU - Lee, D.

AU - Gwack, Y.

AU - Choe, J.

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AB - Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53.

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