The KMDS-NATION study

Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group

Do Young Kwon, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Hae Won Shin, Jinyoung Youn, Kun Woo Park, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong Ho Park, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim & 24 others Sang Myung Cheon, Hee Tae Kim, Jee Young Lee, Ji Sun Kim, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, Hyung Geun Oh, Jinwhan Cho, In Uk Song, Young H. Sohn, philhyu Lee, Jae Woo Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

Original languageEnglish
Pages (from-to)393-402
Number of pages10
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

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Movement Disorders
Parkinson Disease
Quality of Life
Korea
Cognition
Sleep
Demography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kwon, Do Young ; Koh, Seong Beom ; Lee, Jae Hyeok ; Park, Hee Kyung ; Kim, Han Joon ; Shin, Hae Won ; Youn, Jinyoung ; Park, Kun Woo ; Choi, Sun Ah ; Kim, Sang Jin ; Choi, Seong Min ; Park, Ji Yun ; Jeon, Beom S. ; Kim, Ji Young ; Chung, Sun Ju ; Lee, Chong Sik ; Park, Jeong Ho ; Ahn, Tae Beom ; Kim, Won Chan ; Kim, Hyun Sook ; Cheon, Sang Myung ; Kim, Hee Tae ; Lee, Jee Young ; Kim, Ji Sun ; Kim, Eun Joo ; Kim, Jong Min ; Lee, Kwang Soo ; Kim, Joong Seok ; Kim, Min Jeong ; Baik, Jong Sam ; Park, Ki Jong ; Kim, Hee Jin ; Park, Mee Young ; Kang, Ji Hoon ; Song, Sook Kun ; Kim, Yong Duk ; Yun, Ji Young ; Lee, Ho Won ; Oh, Hyung Geun ; Cho, Jinwhan ; Song, In Uk ; Sohn, Young H. ; Lee, philhyu ; Kim, Jae Woo. / The KMDS-NATION study : Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group. In: Journal of Clinical Neurology (Korea). 2016 ; Vol. 12, No. 4. pp. 393-402.
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abstract = "Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1{\%} of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.",
author = "Kwon, {Do Young} and Koh, {Seong Beom} and Lee, {Jae Hyeok} and Park, {Hee Kyung} and Kim, {Han Joon} and Shin, {Hae Won} and Jinyoung Youn and Park, {Kun Woo} and Choi, {Sun Ah} and Kim, {Sang Jin} and Choi, {Seong Min} and Park, {Ji Yun} and Jeon, {Beom S.} and Kim, {Ji Young} and Chung, {Sun Ju} and Lee, {Chong Sik} and Park, {Jeong Ho} and Ahn, {Tae Beom} and Kim, {Won Chan} and Kim, {Hyun Sook} and Cheon, {Sang Myung} and Kim, {Hee Tae} and Lee, {Jee Young} and Kim, {Ji Sun} and Kim, {Eun Joo} and Kim, {Jong Min} and Lee, {Kwang Soo} and Kim, {Joong Seok} and Kim, {Min Jeong} and Baik, {Jong Sam} and Park, {Ki Jong} and Kim, {Hee Jin} and Park, {Mee Young} and Kang, {Ji Hoon} and Song, {Sook Kun} and Kim, {Yong Duk} and Yun, {Ji Young} and Lee, {Ho Won} and Oh, {Hyung Geun} and Jinwhan Cho and Song, {In Uk} and Sohn, {Young H.} and philhyu Lee and Kim, {Jae Woo}",
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language = "English",
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journal = "Journal of Clinical Neurology (Korea)",
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Kwon, DY, Koh, SB, Lee, JH, Park, HK, Kim, HJ, Shin, HW, Youn, J, Park, KW, Choi, SA, Kim, SJ, Choi, SM, Park, JY, Jeon, BS, Kim, JY, Chung, SJ, Lee, CS, Park, JH, Ahn, TB, Kim, WC, Kim, HS, Cheon, SM, Kim, HT, Lee, JY, Kim, JS, Kim, EJ, Kim, JM, Lee, KS, Kim, JS, Kim, MJ, Baik, JS, Park, KJ, Kim, HJ, Park, MY, Kang, JH, Song, SK, Kim, YD, Yun, JY, Lee, HW, Oh, HG, Cho, J, Song, IU, Sohn, YH, Lee, P & Kim, JW 2016, 'The KMDS-NATION study: Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group', Journal of Clinical Neurology (Korea), vol. 12, no. 4, pp. 393-402. https://doi.org/10.3988/jcn.2016.12.4.393

The KMDS-NATION study : Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group. / Kwon, Do Young; Koh, Seong Beom; Lee, Jae Hyeok; Park, Hee Kyung; Kim, Han Joon; Shin, Hae Won; Youn, Jinyoung; Park, Kun Woo; Choi, Sun Ah; Kim, Sang Jin; Choi, Seong Min; Park, Ji Yun; Jeon, Beom S.; Kim, Ji Young; Chung, Sun Ju; Lee, Chong Sik; Park, Jeong Ho; Ahn, Tae Beom; Kim, Won Chan; Kim, Hyun Sook; Cheon, Sang Myung; Kim, Hee Tae; Lee, Jee Young; Kim, Ji Sun; Kim, Eun Joo; Kim, Jong Min; Lee, Kwang Soo; Kim, Joong Seok; Kim, Min Jeong; Baik, Jong Sam; Park, Ki Jong; Kim, Hee Jin; Park, Mee Young; Kang, Ji Hoon; Song, Sook Kun; Kim, Yong Duk; Yun, Ji Young; Lee, Ho Won; Oh, Hyung Geun; Cho, Jinwhan; Song, In Uk; Sohn, Young H.; Lee, philhyu; Kim, Jae Woo.

In: Journal of Clinical Neurology (Korea), Vol. 12, No. 4, 01.10.2016, p. 393-402.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The KMDS-NATION study

T2 - Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group

AU - Kwon, Do Young

AU - Koh, Seong Beom

AU - Lee, Jae Hyeok

AU - Park, Hee Kyung

AU - Kim, Han Joon

AU - Shin, Hae Won

AU - Youn, Jinyoung

AU - Park, Kun Woo

AU - Choi, Sun Ah

AU - Kim, Sang Jin

AU - Choi, Seong Min

AU - Park, Ji Yun

AU - Jeon, Beom S.

AU - Kim, Ji Young

AU - Chung, Sun Ju

AU - Lee, Chong Sik

AU - Park, Jeong Ho

AU - Ahn, Tae Beom

AU - Kim, Won Chan

AU - Kim, Hyun Sook

AU - Cheon, Sang Myung

AU - Kim, Hee Tae

AU - Lee, Jee Young

AU - Kim, Ji Sun

AU - Kim, Eun Joo

AU - Kim, Jong Min

AU - Lee, Kwang Soo

AU - Kim, Joong Seok

AU - Kim, Min Jeong

AU - Baik, Jong Sam

AU - Park, Ki Jong

AU - Kim, Hee Jin

AU - Park, Mee Young

AU - Kang, Ji Hoon

AU - Song, Sook Kun

AU - Kim, Yong Duk

AU - Yun, Ji Young

AU - Lee, Ho Won

AU - Oh, Hyung Geun

AU - Cho, Jinwhan

AU - Song, In Uk

AU - Sohn, Young H.

AU - Lee, philhyu

AU - Kim, Jae Woo

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

AB - Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

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EP - 402

JO - Journal of Clinical Neurology (Korea)

JF - Journal of Clinical Neurology (Korea)

SN - 1738-6586

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