The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder

Je Yeon Yun, Jae Chang Kim, Jeonghun Ku, Jung Eun Shin, Jae Jin Kim, Soo Hee Choi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD. Methods In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis. Results The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD. Limitations Most of participants included in this study were undergraduate students in their early-to-mid 20's. Conclusions This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalJournal of affective disorders
Volume214
DOIs
Publication statusPublished - 2017 May 1

Bibliographical note

Funding Information:
This study was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2014R1A1A1004553) and Aspiring Researcher Program through Seoul National University (SNU) in 2014.

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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