The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients

Hyeong Jin Kim, Chul Woo Ahn, Eun Seok Kang, Sung Min Myoung, Bong Soo Cha, Young Jun Won, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh, Hyun Chul Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). Design: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. Materials and Methods: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5±7.0 years) were determined at baseline and after a mean follow-up time of 23.7±3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. Results: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823±176 to 841±146 μm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794±127 to 882±153 μm (P<.001). Conclusion: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Diabetes and its Complications
Volume21
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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