The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients

Hyeong Jin Kim; Chul Woo Ahn; Eun Seok Kang; Sung Min Myoung; Bong Soo Cha; Young Jun Won; Sung Kil Lim; Kyung Rae Kim; Kap Bum Huh; Hyun Chul Lee

doi:10.1016/j.jdiacomp.2005.11.004

The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients

Hyeong Jin Kim, Chul Woo Ahn, Eun Seok Kang, Sung Min Myoung, Bong Soo Cha, Young Jun Won, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh, Hyun Chul Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). Design: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. Materials and Methods: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5±7.0 years) were determined at baseline and after a mean follow-up time of 23.7±3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA_1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. Results: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA_1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823±176 to 841±146 μm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794±127 to 882±153 μm (P<.001). Conclusion: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.

Original language	English
Pages (from-to)	7-12
Number of pages	6
Journal	Journal of Diabetes and its Complications
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.jdiacomp.2005.11.004
Publication status	Published - 2007 Jan

Bibliographical note

Funding Information:
This study was supported by the Brain Korea 21 Project for Medical Science and by a grant from the National R&D program, Ministry of Science Technology, Republic of Korea (M10104000170-02J0000-07310).

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2005.11.004

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Kim, H. J., Ahn, C. W., Kang, E. S., Myoung, S. M., Cha, B. S., Won, Y. J., Lim, S. K., Kim, K. R., Huh, K. B., & Lee, H. C. (2007). The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients. Journal of Diabetes and its Complications, 21(1), 7-12. https://doi.org/10.1016/j.jdiacomp.2005.11.004

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title = "The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients",

abstract = "Objective: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). Design: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. Materials and Methods: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5±7.0 years) were determined at baseline and after a mean follow-up time of 23.7±3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. Results: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823±176 to 841±146 μm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794±127 to 882±153 μm (P<.001). Conclusion: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.",

author = "Kim, {Hyeong Jin} and Ahn, {Chul Woo} and Kang, {Eun Seok} and Myoung, {Sung Min} and Cha, {Bong Soo} and Won, {Young Jun} and Lim, {Sung Kil} and Kim, {Kyung Rae} and Huh, {Kap Bum} and Lee, {Hyun Chul}",

note = "Funding Information: This study was supported by the Brain Korea 21 Project for Medical Science and by a grant from the National R&D program, Ministry of Science Technology, Republic of Korea (M10104000170-02J0000-07310).",

year = "2007",

month = jan,

doi = "10.1016/j.jdiacomp.2005.11.004",

language = "English",

volume = "21",

pages = "7--12",

journal = "Journal of Diabetes and its Complications",

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T1 - The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients

AU - Kim, Hyeong Jin

AU - Ahn, Chul Woo

AU - Kang, Eun Seok

AU - Myoung, Sung Min

AU - Cha, Bong Soo

AU - Won, Young Jun

AU - Lim, Sung Kil

AU - Kim, Kyung Rae

AU - Huh, Kap Bum

AU - Lee, Hyun Chul

N1 - Funding Information: This study was supported by the Brain Korea 21 Project for Medical Science and by a grant from the National R&D program, Ministry of Science Technology, Republic of Korea (M10104000170-02J0000-07310).

PY - 2007/1

Y1 - 2007/1

N2 - Objective: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). Design: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. Materials and Methods: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5±7.0 years) were determined at baseline and after a mean follow-up time of 23.7±3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. Results: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823±176 to 841±146 μm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794±127 to 882±153 μm (P<.001). Conclusion: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.

AB - Objective: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). Design: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. Materials and Methods: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5±7.0 years) were determined at baseline and after a mean follow-up time of 23.7±3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. Results: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823±176 to 841±146 μm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794±127 to 882±153 μm (P<.001). Conclusion: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.

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The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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