Background The aim was to assess the effect of deep brain stimulation for secondary hemidystonias associated with focal post-traumatic brain injuries. Methods Four patients underwent deep brain stimulation for the treatment of medically refractory secondary hemidystonia associated with post-traumatic brain injury. Clinical outcome assessments were based on Burke-Fahn-Marsden Dystonia Rating Scale movement and disability scores. Health-related quality of life was assessed using a 36-item short-form general health survey questionnaire administered preoperatively and at the last follow-up visit. Results Burke-Fahn-Marsden Dystonia Rating Scale movement scores had improved by 73.2% (range, 38.1-94.1) and disability scores had improved by 75% (range, 60-100) at the 2-year follow-up visit. The health-related quality of life assessment revealed satisfactory results at follow-up, such that body pain, general health, vitality, social functioning, as well as emotional and mental health improved significantly. Conclusions Globus pallidus internus deep brain stimulation can be used to modulate and ameliorate secondary hemidystonia associated with focal post-traumatic brain injury.
Bibliographical noteFunding Information:
The authors would like to thank Eun Jung Kweon (R.N.) for clinical data acquisition and assistance with this paper. We are also grateful to Yong Ho Kwak (Ph.D.), Bae Hwan Lee (Ph.D.) from the MER Analysis team of the Medical Research Support Section, Department of Physiology, Yonsei University College of Medicine for their help with the figures. This study was supported by the Industrial Source Technology Department Program (no.10033812) of the Ministry of Knowledge Economy (MKE) of Korea.
All Science Journal Classification (ASJC) codes
- Clinical Neurology